TABLE 1.  Inheritance Patterns

 

 

 

Risk to offspring

 

Father-to-son transmission

Father-to daughter transmission

 

Disease expression

 

Affected generations

Autosomal dominant

 

50%

yes

yes

variable

multiple

Autosomal recessive

 

25%

yes

yes

less variable

one (unless inbreeding)

X-linked recessive

-50% of sons of carrier female are affected

-50% of daughters of carrier female are carriers

-100% of daughters of carrier male are carriers

 

no

100% of daughters of carrier male are carriers

variable

multiple

 Multifactorial

risk approximately the square root of the population risk

yes

yes

variable

multiple

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published 2000