|
|
|
|
|
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Opioids
|
Preference
|
Inbred strain
Classical analysis
|
Significant genetic influence.
High heritability and dominance
for
morphine preference.
|
|
|
|
Selection
|
Bidirectional shift in morphine
and ethanol
preference.
|
|
|
|
Quantative trait locus
|
Three significant loci:
Chromosomes 8, 10,
12; chromosome 8, ES-1
confirmed within
inbreds.
|
|
|
Conditioned place
preference
Operant self-administration
|
Inbred strain
Inbred strain
|
Predominantly qualitative
differences; not
always similar to preference.
Acquisition dependent upon
history, route,
and access; differences found
in
extinction.
|
|
Cocaline
|
Preference
Conditioned place
preference
Operant self-administration
|
Inbred strain
Inbred strain
Selection
Inbred strain
|
Significant genetic influence.
Significant genetic influence.
Bidirectional shift unrelated
to high-dose
cocaine discrimination.
Significant genetic influence
in similar
direction as ethanol, opioids,
and
diazepam.
|
|
Amphetamine
|
Intracranial self-stimulation
Operant self-administration
|
Within subjects/randomly
inbred rodents
|
Potency and efficacy significantly
influenced
by genotype.
Rate of acquisition correlated
with innate
locomotor behavior.
|
|
Benzodiazapine
|
Operant self-administration
|
Inbred strains
|
Significant genetic influence
in similar
direction as ethanol, opioids,
and
cocaine.
|
|
THC
|
Intracranial self-stimulation
|
Inbred strains
|
Significant genotype-dependent
change;
complements operant studies
with other
drugs.
|