Thoroughly updated and completely reorganized for a sharper clinical focus, the Fifth Edition of this world-renowned classic synthesizes the latest advances in basic neurobiology, biological psychiatry, and clinical neuropsychopharmacology. The book establishes a critical bridge connecting new discoveries in molecular and cellular biology, genetics, and neuroimaging with the etiology, diagnosis, and treatment of the full spectrum of neuropsychiatric disorders. Nine sections focus on specific groups of disorders--disorders of development; schizophrenia and related disorders; anxiety and stress disorders; affective disorders; Alzheimer's and other dementias; substance use disorders; impulsive and compulsive disorders; movement disorders and paroxysmal disorders; and chronobiology and sleep disorders. Each group of disorders is discussed in detail, including clinical course, genetics, neurobiology, neuroimaging, and current and emerging therapeutics. Four sections cover neurotransmitter and signal transduction, emerging methods in molecular biology and genetics, emerging imaging technologies and their psychiatric applications, and drug discovery and evaluation.
Neuropsychopharmacology: The Fifth Generation of Progress Editors: Kenneth L. Davis Dennis Charney Joseph T. Coyle Charles Nemeroff Lippincott, Williams, & Wilkins, Philadelphia, Pennsylvania, 2002
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|  | | Section 1 |
|  | | Neurotransmitter And Signal Transduction (PDF 34Kb)Eric J. Nestler And Ronald S. Duman |
 | | Chapter 1: Acetylcholine (PDF 1506Kb)Marina R. Picciotto, Meenakshi Alreja And J. David Jentsch |
 | | Chapter 2: Serotonin (PDF 635Kb)George K. Aghajanian And Elaine Sanders-Bush |
 | | Chapter 3: Opioid Peptides And Their Receptors: Overview And Function In Pain Modulation (PDF 228Kb)George K. Aghajanian And Elaine Sanders-Bush |
 | | Chapter 4: Norepinephrine (PDF 628Kb)Gary Aston-Jones |
 | | Chapter 5: Regulation Of G Protein-Coupled Receptors By Phosphorylation And Endocytosis (PDF 819Kb)Mark Von Zastrow |
 | | Chapter 6: The Diverse Roles Of L-Glutamic Acid In Brain Signal Transduction (PDF 164Kb)Joseph T. Coyle, Michael L. Leski, and John H. Morrison |
 | | Chapter 7: Corticotropin-Releasing Factor: Physiology, Pharmacology, And Role In Central Nervous System Disorders (PDF 2418Kb)Errol B. De Souza And Dimitri E. Grigoriadis |
 | | Chapter 8: Neurogenesis In Adult Brain (PDF 908Kb)Fred H. Gage And Henriette Van Praag |
 | | Chapter 9: Dopamine (PDF 1689Kb)Anthony A. Grace |
 | | Chapter 10: Astrocytes (PDF 834Kb)Pierre J. Magistretti And Bruce R. Ransom |
 | | Chapter 11: Synaptic Plasticity (PDF 980Kb)Robert C. Malenka |
 | | Chapter 12: Gaba (PDF 1578Kb)Richard W. Olsen |
 | | Chapter 13: Substance P And Related Tachykinins (PDF 119Kb)Nadia M.J. Rupniak Mark S. Kramer |
 | | Chapter 14: Histamine (PDF 165Kb)Jean-Charles Schwartz And Jean-Michel Arrang |
 | | Chapter 15: Purinergic Neurotransmission (PDF 633Kb)Michael Williams |
 | | Chapter 16: Neurotrophic Factors And Intracellular Signal Transduction Pathways (PDF 455Kb)David S. Russell And Ronald S. Duman |
 | | Chapter 17: Regulation Of Gene Expression (PDF 803Kb)Eric J. Nestler And Steven E. Hyman |
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 | | Section 2 |
|  | | Emerging Methods in Molecular Biology and Genetics (PDF 35Kb)Samuel H. Barondes |
 | | Chapter 18: Using Human Genomics To Advance Neuropsychopharmacology (PDF 123Kb)L. Alison Mcinnes and Nelson B. Freimer |
 | | Chapter 19: Gene Targeting And Transgenic Technologies (PDF 576Kb)Laurence H. Tecott And David S. Johnson |
 | | Chapter 20: Gene Delivery Into The Brain Using Viral Vectors (PDF 262Kb)Rachael L. Neve And William A. Carlezon, Jr |
 | | Chapter 21: Neuropsychopharmacology Of Worms And Flies (PDF 154Kb)William R. Schafer |
 | | Chapter 22: Beyond Binding: Molecular And Cell Biological Approaches To Studying G-Protein Coupled Receptors (PDF 3707Kb)Gabriel A. Vargas And Mark Von Zastrow |
 | | Chapter 23: Applying Functional Genomics To Neuropsychopharmacology (PDF 1268Kb)Michael Brownstein |
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 | | Section 3 |
|  | | Emerging Imaging Technologies And Their Application To Psychiatric Research (PDF 39Kb)Robert Desimone |
 | | Chapter 24: Automated 3D Analysis Of Large Brain MRI Databases (PDF 1891Kb)Alan C. Evans |
 | | Chapter 25: In Vivo Magnetic Resonance Spectroscopy Studies Of The Glutamate And GABA Neurotransmitter Cycles And Functional Neuroenergetics (PDF 592Kb)Douglas L. Rothman, Fahmeed Hyder, Nicola Sibson, Kevin L. Behar, Graeme F. Mason, Jun Shen, Ognen A. C. Petroff And Robert G. Shulman |
 | | Chapter 26: The Spatial, Temporal, And Interpretive Limits Of Functional MRI (PDF 2434Kb)Peter A. Bandettini |
 | | Chapter 27: Diffusion Tensor Imaging (PDF 5798Kb)Nikos Makris, G. M. Papadimitriou, A. J. Worth, Bruce G. Jenkins, L. Garrido, A. Gregory Sorensen, V. J. Wedeen, David S. Tuch, O. Wu, Merit E. Cudkowicz, V. S. Caviness Jr., B. R. Rosen And David N. Kennedy |
 | | Chapter 28: Activation Paradigms In Affective And Cognitive Neuroscience: Probing The Neuronal Circuitry Underlying Mood And Anxiety Disorders (PDF 94Kb)Richard J. Davidson |
 | | Chapter 29: Interactions Among Neuronal Systems Assessed With Functional Neuroimaging (PDF 1616Kb)Christian Büchel And Karl Friston |
 | | Chapter 30: Measuring Brain Connectivity With Functional Imaging And Transcranial Magnetic Stimulation (TMS) (PDF 5859Kb)Mark S. George And Daryl E. Bohning |
 | | Chapter 31: In Vivo Molecular Imaging: Ligand Development And Research Applications (PDF 227Kb)Masahiro Fujita And Robert B. Innis |
 | | Chapter 32: Event-Related Potentials And Magnetic Fields In The Human Brain (PDF 725Kb)Steven A. Hillyard And Marta Kutas |
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 | | Section 4 |
|  | | Drug Discovery And Evaluation (PDF 40Kb)Herbert Meltzer |
 | | Chapter 33: The Role Of Preclinical Models In The Development Of Psychotropic Drugs (PDF 104Kb)Mark A. Geyer And Athina Markou |
 | | Chapter 34: Proof Of Concept: Functional Models For Drug Development In Humans (PDF 777Kb)Dean F. Wong, William Z. Potter And James R. Brasic |
 | | Chapter 35: Ethical Aspects Of Neuropsychiatric Research With Human Subjects (PDF 166Kb)Debra A. Pinals And Paul S. Appelbaum |
 | | Chapter 36: Regulatory Issues (PDF 93Kb)Paul Leber |
 | | Chapter 37: Pharmacogenomics And Personalized Therapeutics In Psychiatry (PDF 846Kb)Vural Özdemir, Vincenzo S. Basile, Mario Masellis, Pierandrea Muglia And James L. Kennedy |
 | | Chapter 38: Pharmacokinetics, Pharmacodynamics, And Drug Disposition (PDF 460Kb)David J. Greenblatt, Lisa L. Von Moltke, Jerold S. Harmatz And Richard I. Shader |
 | | Chapter 39: The Role Of Pharmaceuticals In Mental Health Care Outcomes (PDF 142Kb)Ramin Mahmoud, Chris M. Kozma, C. E. Reeder, Amy Grogg And Brian Meissner |
 | | Chapter 40: Issues In Clinical Trial Designs (PDF 93Kb)John M. Kane |
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 | | Section 5 |
|  | | Disorders Of Development (PDF 29Kb)Joseph T. Coyle |
 | | Chapter 41: The Molecular And Cellular Genetics Of Autism (PDF 166Kb)Thomas H. Wassink, James S. Sutcliffe, Veronica J. Vieland And Joseph Piven |
 | | Chapter 42: Current And Emerging Therapeutics Of Autistic Disorder And Related Pervasive Developmental Disorders (PDF 127Kb)Christopher J. McDougle |
 | | Chapter 43: Pathophysiology Of Attention-Deficit/Hyperactivity Disorder (PDF 475Kb)Stephen V. Farone And Joseph Biederman |
 | | Chapter 44: Learning Disorders (PDF 136Kb)C. Keith Conners And Ann C. Schulte |
 | | Chapter 45: Psychosis In Childhood And Its Management (PDF 113Kb)Paramjit T. Joshi And Kenneth E. Towbin |
 | | Chapter 46: Behavioral Phenotypes Of Neurodevelopmental Disorders: Portals Into The Developing Brain (PDF 133Kb)James C. Harris |
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 | | Section 6 |
|  | | Schizophrenia And Related Disorders (PDF 30Kb)Daniel R. Weinberger |
 | | Chapter 47: Schizophrenia: Course Over The Lifetime (PDF 306Kb)Philip D. Harvey And Michael Davidson |
 | | Chapter 48: Neurocognitive Functioning In Patients With Schizophrenia: An Overview (PDF 372Kb)Terry E. Goldberg And Michael F. Green |
 | | Chapter 49: Molecular And Population Genetics Of Schizophrenia (PDF 149Kb)Ming T. Tsuang And Michael J. Owen |
 | | Chapter 50: Animal Models Relevant To Schizophrenia Disorders (PDF 123Kb)Mark A. Geyer And Bita Moghaddam |
 | | Chapter 51: Endophenotypes In Studies Of The Genetics Of Schizophrenia (PDF 171Kb)David L. Braff And Robert Freedman |
 | | Chapter 52: Neurochemistry Of Schizophrenia: Glutamatergic Abnormalities (PDF 200Kb)James H. Meador-Woodruff And Joel E. Kleinman |
 | | Chapter 53: Neural Circuitry Approaches To Understanding The Pathophysiology Of Schizophrenia (PDF 488Kb)David A. Lewis |
 | | Chapter 54: Functional Neuroimaging In Schizophrenia (PDF 121Kb)Karen Faith Berman |
 | | Chapter 55: Structural Magnetic Resonance Imaging Studies In Schizophrenia (PDF 3912Kb)Robert W. Mccarley |
 | | Chapter 56: Therapeutics Of Schizophrenia (PDF 266Kb)Seiya Miyamoto, Gary E. Duncan, Donald C. Goff And Jeffrey A. Lieberman |
 | | Chapter 57: The Economics Of The Treatment Of Schizophrenia (PDF 495Kb)Susan M. Essock, Linda K. Frisman And Nancy H. Covell |
 | | Chapter 58: Mechanism Of Action Of Atypical Antipsychotic Drugs (PDF 131Kb)Herbert Y. Meltzer |
 | | Chapter 59: Neurochemical And Neuropharmacological Imaging In Schizophrenia (PDF 199Kb)Daniel R. Weinberger And Marc Laruelle |
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 | | Section 7 |
|  | | Anxiety And Stress Disorders (PDF 40Kb)Dennis Charney |
 | | Chapter 60: Anxiety And Stress Disorders: Course Over The Lifetime (PDF 86Kb)Murray B. Stein And Ariel J. Lang |
 | | Chapter 61: Genetic And Other Vulnerability Factors For Anxiety And Stress Disorders (PDF 152Kb)Kathleen R. Merikangas And Daniel Pine |
 | | Chapter 62: Animal Models And Endophenotypes Of Anxiety And Stress Disorders (PDF 156Kb)Vaishali P. Bakshi And Ned H. Kalin |
 | | Chapter 63: Neurobiological Basis Of Anxiety Disorders (PDF 321Kb)Dennis S. Charney And Wayne C. Drevets |
 | | Chapter 64: Neural Circuitry Of Anxiety And Stress Disorders (PDF 223Kb)Michael Davis |
 | | Chapter 65: Structural And Functional Imaging Of Anxiety And Stress Disorders (PDF 124Kb)Scott L. Rauch And Lisa M. Shin |
 | | Chapter 66: Current And Emerging Therapeutics Of Anxiety And Stress Disorders (PDF 133Kb)Jack M. Gorman, Justine M. Kent And Jeremy D. Coplan |
 | | Chapter 67: The Economic Burden Of Anxiety And Stress Disorders (PDF 260Kb)Ronald C. Kessler And Paul E. Greenberg |
 | | Chapter 68: Mechanism Of Action Of Anxiolytics (PDF 177Kb)John F. Tallman, James Cassella And John Kehne |
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 | | Section 8 |
|  | | Affective Disorders (PDF 33Kb)Charles Nemeroff |
 | | Chapter 69: The Course Of Depression (PDF 113Kb)Robert J. Boland And Martin B. Keller |
 | | Chapter 70: Risk Factors For Major Depression And Bipolar Disorder (PDF 150Kb)Robert M. A. Hirschfeld And Myrna M. Weissman |
 | | Chapter 71: Bipolar Disorders: Review Of Molecular Genetic Linkage Studies (PDF 128Kb)Wade Berrettini |
 | | Chapter 72: Molecular And Cellular Mechanisms In Depression (PDF 117Kb)Alan F. Schatzberg, Stephen J. Garlow And Charles B. Nemeroff |
 | | Chapter 73: Neurocircuitry Of Mood Disorders (PDF 275Kb)Gregory A. Ordway, Violetta Klimek And J. John Mann |
 | | Chapter 74: Structural And Functional Imaging Of Affective Disorders (PDF 4561Kb)Yvette I. Sheline And Mark A. Mintun |
 | | Chapter 75: Current And Emerging Therapeutics For Depression (PDF 138Kb)A. John Rush And Neal D. Ryan |
 | | Chapter 76: Electroconvulsive Therapy: Sixty Years Of Progress And A Comparison With Transcranial Magnetic Stimulation And Vagal Nerve Stimulation (PDF 213Kb)William M. Mcdonald, W. Vaughn Mccall And Charles M. Epstein |
 | | Chapter 77: Current And Emerging Treatments For Acute Mania And Long-Term Prophylaxis For Bipolar Disorder (PDF 102Kb)Paul E. Keck, Jr. And Husseini K. Manji |
 | | Chapter 78: Cost-Effectiveness Of The Newer Generation Of Antidepressants (PDF 145Kb)Scott W. Woods And C. Bruce Baker |
 | | Chapter 79: Mechanism Of Action Of Antidepressants And Mood Stabilizers (PDF 2680Kb)Robert H. Lenox And Alan Frazer |
 | | Chapter 80: Hormonal And Gender Influences On Mood Regulation (PDF 130Kb)David R. Rubinow, Peter J. Schmidt And Catherine A. Roca |
 | | Chapter 81: Depression And The Medically Ill (PDF 573Kb)Robert G. Robinson And K. Ranga Rama Krishnan |
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 | | Section 9 |
|  | | Alzheimer And Other Dementias (PDF 35Kb)Kenneth L. Davis |
 | | Chapter 82: Alzheimer Disease: From Earliest Symptoms To End Stage (PDF 95Kb)Richard C. Mohs And Vahram Haroutunian |
 | | Chapter 83: Molecular Genetics Of Alzheimer Disease (PDF 197Kb)S. Parvathy And Joseph D. Buxbaum |
 | | Chapter 84: Transgenic Mouse Models Of Alzheimer Disease (PDF 68Kb)Karen Duff |
 | | Chapter 85: Cell And Molecular Neuropathology Of Alzheimer Disease (PDF 102Kb)Ralph A. Nixon |
 | | Chapter 86: Structural And Functional Brain Imaging Of Alzheimer Disease (PDF 1681Kb)Gary W. Small |
 | | Chapter 87: Current And Experimental Therapeutics Of Alzheimer Disease (PDF 104Kb)Kenneth L. Davis |
 | | Chapter 88: Alzheimer Disease: Treatment Of Noncognitive Behavioral Abnormalities (PDF 217Kb)Murray A. Raskind Robert F. Barnes |
 | | Chapter 89: Cost-Effectiveness Of Therapeutics For Alzheimer Disease (PDF 128Kb)Andrea Manca, Linda Davies And Alistair Burns |
 | | Chapter 90: Neuropsychiatric Manifestations Of HIV-1 Infection And AIDS (PDF 175Kb)Dwight L. Evans, Karen I. Mason, Jane Leserman, Russell Bauer And John Petitto |
 | | Chapter 91: Dementia With Lewy Bodies (PDF 1939Kb)Ian G. McKeith, David Burn, John O’Brien, Robert Perry And Elaine Perry |
 | | Chapter 92: Molecular Pathophysiology Of Stroke (PDF 197Kb)Steven H. Graham And Robert W. Hickey |
 | | Chapter 93: Current And Experimental Treatment Of Stroke (PDF 1411Kb)Daniel L. Small, Paul Morley And Alastair M. Buchan |
 | | Chapter 94: Tau Protein And Tauopathy (PDF 481Kb)Makoto Higuchi, John Q. Trojanowski And Virginia M.-Y. Lee |
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 | | Section 10 |
|  | | Substance Use Disorders (PDF 29Kb)Charles P. O'Brien And Marian W. Fischman |
 | | Chapter 95: Neurocircuitry Of Addiction (PDF 360Kb)Peter W. Kalivas |
 | | Chapter 96: Molecular And Cellular Biology Of Addiction (PDF 204Kb)Kathy L. Kopnisky And Steven E. Hyman |
 | | Chapter 97: Recent Advances In Animal Models Of Drug Addiction (PDF 268Kb)Toni S. Shippenberg And George F. Koob |
 | | Chapter 98: Vulnerability Factors For Alcoholism (PDF 131Kb)Marc A. Schuckit |
 | | Chapter 99: Molecular And Cellular Genetics Of Alcohol Addiction (PDF 125Kb)Mary-Anne Enoch And David Goldman |
 | | Chapter 100: Ethanol Abuse, Dependence, And Withdrawal: Neurobiology And Clinical Implications (PDF 1958Kb)John H. Krystal Boris Tabakoff |
 | | Chapter 101: Alcoholism Pharmacotherapy (PDF 328Kb)Joseph R. Volpicelli, Suchitra Krishnan-Sarin And Stephanie S. O'Malley |
 | | Chapter 102: Pathophysiology And Treatment Of Cocaine Dependence (PDF 120Kb)Thomas R. Kosten |
 | | Chapter 103: Application Of Imaging Technologies In The Investigation Of Drug Addiction (PDF 3386Kb)Nora D. Volkow And Joanna S. Fowler |
 | | Chapter 104: Molecular And Cellular Neurobiology And Pathophysiology Of Opiate Addiction (PDF 145Kb)Mary Jeanne Kreek |
 | | Chapter 105: Current And Experimental Therapeutics For The Treatment Of Opioid Addiction (PDF 109Kb)Paul J. Fudala And George E. Woody |
 | | Chapter 106: Marijuana (PDF 128Kb)Billy R. Martin, William L. Dewey, And Vincenzo Di Marzo |
 | | Chapter 107: Therapeutics For Nicotine Addiction (PDF 108Kb)Reese T. Jones And Neal L. Benowitz |
 | | Chapter 108: Psychedelic Drugs (PDF 1042Kb)Henry David Abraham, Una D. Mccann, And George A. Ricaurte |
 | | Chapter 109: Epidemiology Of Drug Dependence (PDF 1005Kb)James C. Anthony |
 | | Chapter 110: Neuroimaging Of Cocaine Craving States: Cessation, Stimulant Administration, And Drug Cue Paradigms (PDF 3637Kb)A. R. Childress, Teresa R. Franklin, J. Listerud, Paul D. Acton And Charles P. O'Brien |
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 | | Section 11 |
|  | | Impulsive And Compulsive Disorders (PDF 31Kb)Eric Hollander |
 | | Chapter 111: The Course And Clinical Features Of Obsessive-Compulsive Disorder (PDF 155Kb)Steven A. Rasmussen And Jane L. Eisen |
 | | Chapter 112: The Pathophysiology And Genetics Of Obsessive-Compulsive Disorder (PDF 112Kb)David L. Pauls, Emanuela Mundo And James L. Kennedy |
 | | Chapter 113: Imaging And Neurocircuitry Of OCD (PDF 10893Kb)David R. Rosenberg And Shauna N. Macmillan |
 | | Chapter 114: Current And Experimental Therapeutics Of OCD (PDF 155Kb)Eric Hollander And Stefano Pallanti |
 | | Chapter 115: The Behavioral Neuroscience Of Eating (PDF 182Kb)Gerard P. Smith And Nori Geary |
 | | Chapter 116: Psychopharmacology Of Eating Disorders (PDF 114Kb)Walter H. Kaye And B. Timothy Walsh |
 | | Chapter 117: Tourette Syndrome And Related Tic Disorders (PDF 133Kb)Neal R. Swerdlow And James F. Leckman |
 | | Chapter 118: Animal Models Of Aggression (PDF 109Kb)Berend Olivier And Larry J. Young |
 | | Chapter 119: Pathophysiology And Treatment Of Aggression (PDF 140Kb)Emil F. Coccaro And Larry J. Siever |
 | | Chapter 120: Pathologic Gambling And Impulse Control Disorders (PDF 708Kb)Mark N. Potenza And Eric Hollander |
 | | Chapter 121: Compulsive And Impulsive Aspects Of Self-Injurious Behavior (PDF 124Kb)Dan J. Stein, Joseph Zohar, And Daphne Simeon |
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 | | Section 12 |
|  | | Movement Disorders And Paroxysmal Disorders (PDF 36Kb)Carol Tamminga |
 | | Chapter 122: Neurocircuitry Of Parkinson's Disease (PDF 1261Kb)Thomas Wichmann And Mahlon R. Delong |
 | | Chapter 123: Pathophysiology Of Parkinson’s Disease (PDF 130Kb)Michael J. Zigmond And Robert E. Burke |
 | | Chapter 124: Current And Experimental Therapeutics Of Parkinson’s Disease (PDF 184Kb)Jean-Michel Gracies And C. Warren Olanow |
 | | Chapter 125: Huntington Disease (PDF 1239Kb)Christopher A. Ross And Russell L. Margolis |
 | | Chapter 126: Clinical Course And Cellular Pathology Of Tardive Dyskinesia (PDF 1276Kb)Carol A. Tamminga And Margaret G. Woerner |
 | | Chapter 127: Temporal Lobe Epilepsy: Renewed Emphasis On Extrahippocampal Areas (PDF 2536Kb)Robert Schwarcz, Helen E. Scharfman And Edward H. Bertram |
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 | | Section 13 |
|  | | Chronobiology And Sleep Disorders (PDF 41Kb)David J. Kupfer |
 | | Chapter 128: Basic Mechanisms Of Sleep: New Evidence On The Neuroanatomy And Neuromodulation Of The Nrem-Rem Cycle (PDF 445Kb)Edward F. Pace-Schott And J. Allan Hobson |
 | | Chapter 129: Circadian Phase Sleep And Mood Disorders (PDF 467Kb)Jacqueline D. Kloss, Martin P. Szuba And David F. Dinges |
 | | Chapter 130: Sleep Loss And Sleepiness: Physiological And Neurobehavioral Effects (PDF 195Kb)Jacqueline D. Kloss, Martin P. Szuba And David F. Dinges |
 | | Chapter 131: Pathophysiological And Pharmacologic Aspects Of The Sleep Disorder Narcolepsy (PDF 148Kb)Emmanuel Mignot And Seiji Nishino |
 | | Chapter 132: Basic Mechanisms Of Sedative/Hypnotics (PDF 87Kb)Wallace B. Mendelson |
 | | Chapter 133: Current And Experimental Therapeutics Of Insomnia (PDF 180Kb)Daniel J. Buysse And Cynthia M. Dorsey |
 | | Chapter 134: Sleep Disturbances Associated With Neuropsychiatric Disease (PDF 1101Kb)Eric A. Nofzinger And Matcheri Keshavan |
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