Volume Two


 Volume Two

nppr

CNS Drug Discovery & Development:  Challenges and Opportunities

Table of Contents

VOLUME 2

EDITORIAL: 'CNS Drug Discovery and Development: When Will We Rescue Tantalus?' Neuropsychopharmacology Reviews Volume 2 on CNS Drug Discovery and Development: Challenges and Opportunities
Husseini K Manji and Errol B DeSouza

COMMENTARY: Physician-Scientist's Frustrations Fester
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Floyd E Bloom

REVIEWS
The Medical and Economic Roles of Pipeline Pharmacogenetics: Alzheimer's Disease as a Model of Efficacy and HLA-B*5701 as a Model of Safety
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Target Identification for CNS Diseases by Transcriptional Profiling
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In Vitro and In Vivo Pharmacological Models to Assess Demyelination and Remyelination
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Removing Obstacles in Neuroscience Drug Discovery: The Future Path for Animal Models
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Non-Human Primates: Model Animals for Developmental Psychopathology
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Drugability of Extracellular Targets: Discovery of Small Molecule Drugs Targeting Allosteric, Functional, and Subunit-Selective Sites on GPCRs and Ion Channels
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Small Molecule Protein-Protein Interaction Inhibitors as CNS Therapeutic Agents: Current Progress and Future Hurdles
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Novel Therapeutic Modalities to Address Nondrugable Protein Interaction Targets
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Pharmacogenomics:  The Promise of Personalized Medicine for CNS Disorders
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Metabolomics:  A Global Biochemical Approach to the Study of Central Nervous System Diseases
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The Role of Imaging in Proof of Concept for CNS Drug Discovery and Development
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Bridging Bench and Practice: Translational Research for Schizophrenia and Other Psychotic Disorders
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Challenges in Developing Novel Treatments for Childhood Disorders: Lessons from Research on Anxiety
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NIMH Initiatives to Facilitate Collaborations Among Industry, Academia, and Government for the Discovery and Clinical Testing of Novel Models and Drugs for Psychiatric Disorders
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HOT TOPICS
Adult neurogenesis, cell cycle and drug discovery in psychiatry
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Targeting nicotinic receptor antagonists as novel pharmacotherapies for tobacco dependence and relapse
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RNA editing as a therapeutic target for CNS disorders
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The dynorphin / kappa opioid receptor system: a new target for the treatment of addiction and affective disorders?
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Protein-protein interactions as therapeutic targets in neuropsychopharmacology
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Promise of mGluR2/3 activators in psychiatry
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Targeting AMPA and kainate receptors in neurological disease: therapies on the horizon?
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Gene expression profiling in blood: new diagnostics in alcoholism and addiction?
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From rapid In Vitro screening to rapid In Vivo screening in the drug discovery process
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Targeting the serotonin 2c receptor for the treatment of obesity and type 2 diabetes
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Turning up the pace of ion channel screening in drug discovery
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Lewy body pathology in long-term fetal nigral transplants: is parkinson's disease transmitted from one neural system to another?
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