TABLE 3.  Substrates of debrisoquin hydroxylase (CYP2D6) and mephenytoin hydroxylase (CYPmp)

Substrates of CYP2D6

 

 

Psychoactive agents

Cardiovascular agents

Other agents

Substrates of CYPmp

Neuroleptics

Clozapine

Fluphenazine

Haloperidol

Perphenazine

Risperidone

Thioridazine

Trifluperidol

Heterocyclic antidepressants

Amitriptyline

Clomipramine

Desipramine

Imipramine

Nortriptyline

Selective serotonin-receptor inhibitors

Fluoxetine

Paroxetine

Tomoxetine

Antiarrhythmics

Encainide

Flecainide

Mexiletine

N-Propylajmaline

Sparteine

Beta-blockers

Bufuralol

Metoprolol

Propranolo

Timolol

Antihypertensives

Indoramin

Debrisoquine

Guanoxan

Codeine

Dextromethorphana

Methoxyamphetamine

Perhexilence

Phenformin

Desipramine

Diazepam

Demethyldiazepam

Hexobarbital

Imipramine

Mephebarbital

Mephenytoin

Omeprazole

Propranolol

 

Monoamine inhibitors

Amiflamine

Methoxyphenamine

 

a Frequently used instead of debrisoquine to characterize the polymorphic status of CYP2D6.
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published 2000