TABLE 2. Worldwide distribution of the percentage of  poor

metabolizers (PMs) of debrisoquine hydroxylase (CYP2D6) and

mephenytoin  hydroxylase (CYPmp)

 

Population

Debrisoquine

hydroxylase

Mephenytoin

hydroxylase

Caucasians

3-9.2%

2.5-6.7%

Arabians/Egyptians

1-1.4%

?

Asian Indians

?

20.8%

East Asians

0-2.4%

17.4-22%

Amerindians

0-5.2%

0%

Hispanics

4.5%

4.8%

Subsaharan Africans

0-8.1%

?

Sans Bushman

19%

?

African-Americans

1.9%

18.5%
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published 2000