Psychiatric Genetic Counseling / Table 6

TABLE 6. Risks to mental disorders for a child born into a five-member family

										Affected Parents
				0						1											2
										Affected Siblings
			0			1		2		0			1				2			0			1		2
										Affection status, second-degree relative¹
		U			A	U	A	U	A	U	A		U	A		U		A		U		A	U	A	U	A
Disorder	Population Rate										ss	os²		ss	os²			ss	os²
Schizophrenia	1%	1			2	6	9	14	18	6	8	15	16	18	25	27		31	36	33		37	42	47	52	57
Bipolar disorder	0.8%	1			2	5	8	13	17	6	7	14	15	17	24	26		29	35	32		36	41	46	51	56
Severe depression (male)	4%	3			4	6	8	10	12	6	7	8	10	12	13	15		18	19	13		15	18	21	24	28
(female)	8%	6			8	11	14	18	21	12	14	15	18	21	22	26		29	30	22		25	29	33	37	41
Alcoholism (male)	14%	10			16	22	29	35	42	24	30	32	38	43	45	50		56	57	45		52	57	63	67	72
(female)	3%	2			3	5	7	9	11	5	7	8	9	11	12	14		16	17	12		15	17	20	23	26

¹ U = unaffected; A = affected; ² ss = same side as affected parent; os = opposite side as affected parent. Risks are shown for a child born into a family with two siblings, two parents, and one female second-degree relative. Risks of schizophrenia or bipolar disorder are the same for a male or female at-risk child; population rates are in males and females. When one parent is affected, it is the mother.

(Reprinted with permission. Moldin SO. Psychiatric genetic counseling. In: Guze SB, ed. Washington University adult psychiatry. St. Louis: Mosby, 1997.)

Back to Chapter