Psychopharmacology of Anorexia Nervosa, Bulimia Nervosa, and Binge Eating / Table 1

TABLE 1. Summary of controlled outpatient trials of antidepressants in bulimia^a

				Change in binge frequency (%)^b		Remission (%)
Author	N	Design	Medication	Drug	Placebo	Drug	Placebo
Pope et al. (45)	19	Parallel	Imipramine^c	-70.0	0.0	NR^d	NR
Sabine et al. (50)	36	Parallel	Mianserin	NR	NR	NR	NR
Mitchell and Groat (42)	32	Parallel	Amitriptyline	-72.1	-51.8	NR	NR
Hughes et al. (32)	22	Parallel	Desipramine^c	-91.0	19.0	NR	NR
Barlow et al. (4)	24	Crossover	Desipramine^c	-46.8	-2.4	2.4	NR
Agras et al. (1)	20	Parallel	Imipramine^c	-72.4	-43.1	30.0	10.0
Blouin et al. (7)	10	Crossover	Desipramine^c	-40.0	NR	10.0	NR
Horne et al. (29)	81	Parallel	Bupropion^c	-67.0	-1.9	29.7	NR
Walsh et al. (58)	50	Parallel	Phenelzine^c	-64.2	-5.5	34.8	3.7
Kennedy et al. (35)	18	Crossover	Isocarboxazid^c	-35.0	5.0	33.3	NR
Pope et al. (46)	42	Parallel	Trazodone^c	-31.0	21.0	10.0	0.0
Mitchell et al. (43)	74^e	Parallel	Imipramine^c	-49.3	-2.5	16.0	NR
Fluoxetine Bulimia Nervosa	387	Parallel	Fluoxetine (60 mg)^c	-67	-33	27^f	14^f
Collaborative Study Group (22)			Fluoxetine (20 mg)	-45		14^f
Freeman et al. (24)	40	Parallel	Fluoxetine^c	-51.4	-16.8	NR	NR
Walsh et al. (59)	78	Parallel	Desipramine^c	-47.0	7.0	12.5	7.9
Potvin et al. (47)	398	Parallel	Fluoxetine^c	-50	-18	NR	NR
Alger et al. (3)	14	Parallel	Imipramine	-20	-30	NR	NR
Kennedy et al. (34)	36	Parallel	Brofaromine	-61.5	-50.0	19	13

^a Adapted from ref. 57, with permission.

^bMean of individual subjects’ percent reduction in binge frequency is given where available; otherwise percent reduction in group mean binge frequency is given.

^c Statistically significant difference between active medication and placebo.

^d NR, not reported.

^e This study also examined the effects of group psychotherapy. These 74 patients received only imipramine or placebo.

^f Approximate figures.

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