TABLE 3.  Right-left metabolic asymmetries [Eq. (1)] in control subjects and in AD patients of differing dementia severitya,b

 

Right-left metabolic asymmetries

 

Brain regions

Controls

(31)

Mild AD

(11)

Moderate AD

(13)

Severe AD

(8)

Association cortex

 

 

 

 

Perfrontal

0.01 ± 0.03

-0.01 ± 0.07*

-0.01 ± 0.08***

0.05 ± 0.10***

Premotor

0.01 ± 0.05

-0.01 ± 0.10**

-0.02 ± 0.16***

0.05 ± 0.11**

Orbitofrontal

-0.01 ± 0.06

-0.03 ± 0.08

-0.03 ± 0.11**

0.00 ± 0.11*

Parietal

-0.01 ± 0.06

-0.01 ± 0.11*

-0.03 ± 0.13*

0.08 ± 0.13*

Lateral temporal

-0.01 ± 0.07

-0.05 ± 0.17**

-0.03 ± 0.18***

0.08 ± 0.23***

 

 

 

 

 

Primary cortex

 

 

 

 

Sensorimotor

-0.02 ± 0.05

-0.01 ± 0.07

0.00 ± 0.06

0.01 ± 0.08

Occipitalc

-0.01 ± 0.04

0.00 ± 0.05

-0.01 ± 0.03

0.03 ± 0.08*

   a Values are means ± SD (number of subjects). Scanditronix PC 1024-7B data from ref. 31.

   b Variance greater than in controls: * p < 0.05; ** p < 0.01; *** p < 0.001.

   c  Primary and unimodal association cortex.

 

 

 

 

published 2000