TABLE 1.  Cognitive profiles for AD patients with mild or moderate dementiaa,b

 

Neuropsychological test

Controls

(N = 21-29)

Mild AD

(N = 11)

Moderate AD

(N = 13)

Omnibus Tests

Wechsler intelligence scale

 

 

 

 

Full - scale IQ

126 ± 10

117 ± 8

  92 ± 17**

Deviation quotients

 

 

 

Verbal comprehension

129 ± 10

123 ± 9

102 ± 17**

Memory and distractibility

116 ± 13

113 ± 8

  90 ± 15**

Perceptual organization

119 ± 13

109 ± 13

  84 ± 26**

 

 

 

 

Memory

 

 

 

Wechsler memory scale

 

 

 

Immediate story recall

  22 ± 15

  11 ± 15**

    5 ± 3**

Immediate figure recall

  10 ± 3

    7 ± 4*

    1 ± 2**

Delayed story recall

  17 ± 5

    2 ± 4**

    1 ± 1**

Delayed figure recall

    7 ± 3

    1 ± 1**

    0 ± 1**

 

 

 

 

Attention, planning and abstract reasoning

 

 

 

Trailmaking (Trail A) (sec)

  40 ± 17

  54 ± 30

153 ± 98**

Trailmaking (Trail B) (sec)

  82 ± 40

192 ± 155*

428 ± 139**

Stroop color- word inference, no/45s

  37 ± 8

  24 ± 8*

  12 ± 8**

Porteus mazes (age in years)

 15.4 ± 1.6

12.8 ± 3.9

 7.7 ± 3.8**

 

 

 

 

Language

 

 

 

Syntax comprehension

 24 ± 2

  23 ±  2

  17 ± 5**

Controlled word association (FAS)

 42 ± 2

  34 ± 13

  25 ± 12**

Boston naming

 37 ± 4

  35 ± 7

  25 ± 8**

 

 

 

 

Visuospatial Function

 

 

 

Extended range drawing

 21 ± 2

  19 ± 4

 13 ± 5**

Hiskey - Nebraska block patterns

 15 ± 4

  11 ± 5

   4 ± 3**

Benton facial recognition

 44 ± 4

  42 ± 5

 39 ± 5*

   a  Neuropsychological tests classified by cognitive sphere that they are considered to evaluate.

      Data from ref. 31.

   b  Mean ± SD differs from control mean, * p < 0.05; * *  p < 0.001.

 

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published 2000