|
Scopolamine
|
10
10
10
6
|
AD
NC
AD
NC
|
0.1, 0.25, 0.5 mg i.v.
0.1-0.5 mg i.m.
|
{ewc MVIMG, MVIMAGE,!uparrow.bmp}
Cognitive and behavioral
sensitivity
{ewc MVIMG, MVIMAGE,!uparrow.bmp}
Cognitive sensitivity in AD
|
66
32a
|
|
Arecoline
|
12
15
6
4
|
AD
AD
AD
NC
|
1, 2, 4 mg/liter i.v.
5 mg i.v.
4 mg i.v.
|
No cognitive improvement
No cognitive improvement
{ewc MVIMG, MVIMAGE,!uparrow.bmp}
CSF HVA in AD versus controls
|
70
58
56a
|
|
Physostigmine
|
12
11
10
10
12
12
|
AD
Dementia
AD
AD
AD
NC
|
0.75 mg i.v.
0.004-0.013 mg/kg i.m.
0.50 mg i.v. + variable
infusion
60 mg/kg p.o.
0.0125 mg/kg i.v.
|
{ewc MVIMG, MVIMAGE,!uparrow.bmp}
Picture recognition
{ewc MVIMG, MVIMAGE,!uparrow.bmp}
Selective reminding, {ewc MVIMG, MVIMAGE,!dnarrow.bmp} intrusions
{ewc MVIMG, MVIMAGE,!uparrow.bmp}
Reaction time, no memory {ewc MVIMG, MVIMAGE,!uparrow.bmp}
{ewc MVIMG, MVIMAGE,!uparrow.bmp}
Plasma cortisol & {ewc MVIMG, MVIMAGE,!dnarrow.bmp} cholinesterase
{ewc MVIMG, MVIMAGE,!dnarrow.bmp}
Plasma vasopressin, endorphin,
epinephrine versus controls
|
7
63
27
37
60
|
|
Edrophonium
|
14
8
12
8
|
AD
NC
AD
NC
|
0.13/kg i.v.
0.15 mg/kg i.v.
|
{ewc MVIMG, MVIMAGE,!dnarrow.bmp}
GH response versus control
No difference versus controls
|
71
16
|
|
Nictotine
|
6
11
|
AD
AD
|
0.125, 0.25, 0.5 mg/kg/
min
0.125, 0.25, 0.5 mg/kg/
min i.v.
|
{ewc MVIMG, MVIMAGE,!dnarrow.bmp}
Intrusion errors
{ewc MVIMG, MVIMAGE,!uparrow.bmp}
Prolactin in AD. no difference from
controls for ACTH, cortisol
|
50
48
|