FIG. 2

Diagram showing the structural domains of APP and the position of disease causing mutations with respect to the sites of cleavage by proteolytic processing enzymes (a, b, and g secretase). The black box represents b-A4, and {ewc MVIMG, MVIMAGE,!vertline.bmp}•— —•{ewc MVIMG, MVIMAGE,!vertline.bmp} represents the plasma membrane.

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published 2000