TABLE 1. Serotonin function in psychiatric disorders

Azapirone

SSRI

Inhibitory pathways

Stimulatory pathways

Orbitofrontal cortex

GH response to clonidine

GAD + ? - {ewc MVIMG, MVIMAGE,!uparrow.bmp} ¾ {ewc MVIMG, MVIMAGE,!dnarrow.bmp}
Panic disorder
    ¾
 + {ewc MVIMG, MVIMAGE,!dnarrow.bmp} brainstm {ewc MVIMG, MVIMAGE,!uparrow.bmp} ¾ {ewc MVIMG, MVIMAGE,!dnarrow.bmp}
OCD
    + ?
 + - {ewc MVIMG, MVIMAGE,!dnarrow.bmp} {ewc MVIMG, MVIMAGE,!dnarrow.bmp} ¾
Depression + + {ewc MVIMG, MVIMAGE,!dnarrow.bmp} limbic {ewc MVIMG, MVIMAGE,!uparrow.bmp} ¾ {ewc MVIMG, MVIMAGE,!dnarrow.bmp}

GAD, generalized anxiety disorder; OCD, obsessive-compulsive disorder.

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published 2000