TABLE 4. Affinities of representative typical and atypical antipsychotic drugs for cloned 5-HT receptors

Drugs

 5-HT2AKi

(nM)

 5-HT2CKi

(nM)

 5-HT6Ki

(nM)

 5-HT7Ki

(nM)

Spiperone

0.33

1595

1095

9.9

Loxapine

0.82

9.4

14.9

43

Chlorpromazine

2.3

27

4.1

21

Clozapine

4

7.2

4.5

6.3

Fluperlapine

6.7

18.2

16.5

13.9

Haloperidol

41.6

2320

 >5000

262

MDL 100907

0.2

18

 >5000 ND

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published 2000