TABLE 1. Plasma homovanillic acid studies in schizophrenia: treatment studiesa

Reference Subjects (N) Duration Dose/day Result
Bowers et al. (48) PSYCHOT* (29) 10 days HAL 0.2 - 0.4 mg/kg pHVA {ewc MVIMG, MVIMAGE,!uparrow.BMP} in responders
Pickar et al. (56) SCZ (16) 5 weeks FLU 30 mg pHVA {ewc MVIMG, MVIMAGE,!dnarrow.BMP}, week 3-5
Davila et al. (45) SCZ (14) 4 weeks HAL 10 mg

FLU 27 mg + ALP

pHVA {ewc MVIMG, MVIMAGE,!uparrow.BMP}, day 4

Wolkowitz et al. (51) SCZ (12) 10 weeks 2.9 mg

PER 0.5 mg/kg +

pHVA {ewc MVIMG, MVIMAGE,!dnarrow.BMP} in responders
Bowers et al. (95) PSYCHOT** (37)

SCZ (11)

9 days HAL 0.2 mg/kg pHVA {ewc MVIMG, MVIMAGE,!dnarrow.BMP}, day 7-9

DpHVA: responders >

Sharma et al. (47) PSYCHOT (6) 4 weeks TFP 40 mg nonresponders, pHVA = , week 4
Chang et al. (49) SCZ (33) 6 weeks HAL 20 mg pHVA {ewc MVIMG, MVIMAGE,!dnarrow.BMP} in responders
Davidson et al. (23) SCZ (30) 6 weeks HAL 20 mg pHVA {ewc MVIMG, MVIMAGE,!uparrow.BMP}, day 1
Davidson et al. (57) SCZ (20) 5 weeks HAL 20 mg pHVA {ewc MVIMG, MVIMAGE,!dnarrow.BMP} in responders
Pickar et al. (60) SCZb (21) 12 weeks CLZ 300 - 900 mg pHVA {ewc MVIMG, MVIMAGE,!dnarrow.BMP} responders > nonresponders

aAbbreviations in Tables 1-4. SCZ, schizophrenic patients; NC, normal controls; PSYCHOT, patients suffering from different psychotic disorders; pHVA, plasma homovanillic acid concentration; HAL, haloperidol; PER, perphenazine; TFP, trifluoperazine; r, correlation coefficient; ns, not significant; *, only two patients were schizophrenic; * *, only four patients were schizophrenic; =, no change; {ewc MVIMG, MVIMAGE,!uparrow.BMP}, increase; {ewc MVIMG, MVIMAGE,!dnarrow.BMP}, decrease.

bThree patients were schizoaffective (DSM III R).

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published 2000