Functional Brain Imaging Studies in Schizophrenia

Raquel E. Gur


REFERENCES

1. Anderson J, Fawdry R, Gordon E, Coyle S, Gruenewald S, Meares RA. SPECT asymmetry of left temporal lobe in hallucinated schizophrenics. Biol Psychiatry 1991;29:291.

2. Andreasen NC, Carson R, Diksic M, et al. PET and dopamine D2 receptors in the human neostriatum. Schizophr Bull 1988;14:471-484.

3. Andreasen NC, Rezai K, Alliger R, et al. Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia: Assessment with Xenon 133 single-photon emission computed tomography and the tower of London. Arch Gen Psychiatry 1992;49:943-958.

4. Bartlett EJ, Barouche F, Brodie JD, et al. Stability of resting deoxyglucose metabolic values in PET studies of schizophrenia. Psychiatry Res 1991;40:11-20.

5. Bartlett EJ, Woklin A, Brodie JD, Laska EM, Wolf AP, Sanfilipo M. Importance of pharmacologic control in PET studies: Effects of thiothixene and haloperidol on cerebral glucose utilization in chronic schizophrenia. Psychiatry Res 1991;40:115-124.

6. Berman KF, Ostrem JL, Randolph C, et al. Physiological activation of a cortical network during performance of the Wisconsin card sorting test: A positron emission tomography study. Neuropsychologia 1995;33:1027-1046.

7. Berman KF, Weinberger DR. Lateralization of cortical function during cognitive tasks: regional cerebral blood flow studies of normal individuals and patients with schizophrenia. J Neurol Neurosurg Psychiatry 1990;53:150-160.

8. Biver F, Goldman S, Luxen A, et al. Altered frontostriatal relationship in unmedicated schizophrenic patients. Psychiatry Res 1995;61:161-171.

9. Bogerts B, Falkai P, Greve B. Evidence of reduced temporolimbic structure volumes in schizophrenia letter. Arch Gen Psychiatry 1991;48:956-958.

10. Brucke T, Tsai YF, McLellan CA, et al. In vitro binding properties and autoradiographic imaging of 3-iodobenzamide ([125I]-IBZM): a potential imaging ligand for D2 dopamine receptors in SPECT. Life Sci 1988;42:2097-2104.

11. Buchsbaum MS, Ingvar DH, Kessler R, et al. Cerebral glucography with positron tomography. Arch Gen Psychiatry 1987;39:251-259.

12. Buchsbaum MS, Potkin SG, Marshall JF, et al. Effects of clozapine and thiothixene on glucose metabolic rate in schizophrenia. Neuropsychopharmacology 1992;6:155-163.

13. Buchsbaum MS, Potkin SG, Siegel BV, Jr, et al. Striatal metabolic rate and clinical response to neuroleptics in schizophrenia. Arch Gen Psychiatry 1992;49:966-974.

14. Buchsbaum MS, Someya T, Teng CY, et al. PET and MRI of the thalamus in never-medicated patients with schizophrenia. Am J Psychiatry 1996;153:191-199.

15. Buchsbaum MS. The frontal lobes, basal ganglia, and temporal lobes as sites for schizophrenia. Schizophr Bull 1990;16:377-387.

16. Chumpradit S, Kung M-P, Billings J, Mach R, Kung HF. Fluorinated and iodinated dopamine agents (FIDA): D2 imaging agents for PET and SPECT. J Med Chem 1993;36:221-228.

17. Cleghorn J.M, Garnett ES, Nahmias C, et al. Increased frontal and reduced parietal glucose metabolism in acute untreated schizophrenia. Psychiatry Res 1989;28:119-133.

18. Cleghorn JM. Regional brain metabolism during auditory hallucinations in chronic schizophrenia. Br J Psychiatry 1990;157:562-570.

19. Crow TJ. Temporal lobe asymmetries as the key to the etiology of schizophrenia. Schizophr Bull 1990;16:433-443.

20. Davis KL, Kah RS, Ko G, Davidson M. Dopamine in schizophrenia: a review and reconceptualization. Am J Psychiatry 1991;148:1474-1486.

21. DeLisi LE, Buchsbaum MS, Holcomb HH, et al. Increased temporal lobe glucose use in chronic schizophrenic patients. Biol Psychiatry 1989;25(7):835-851.

22. DeLisi LE, Holcomb HH, Cohen RM, et al. Positron emission tomography in schizophrenic patients with and without neuroleptic medication. J Cereb Blood Flow Metab 1985;5:201-206.

23. Dolan RJ, Fletcher P, Frith CD, Friston KJ, Frackowiak RS, Grasby PM. Dopaminergic modulation of impaired cognitive activation in the anterior cingulate cortex in schizophrenia. Nature 1995;378:180-182.

24. Early TS, Reiman EM, Raichle, ME, Spitznagel EL. Left globus pallidus abnormality in never-mediated patients with schizophrenia. Proc Natl Acad Sci USA 1989;84:561-563.

25. Farde L, Nordstrom AL. PET analysis indicates atypical central dopamine receptor occupancy in clozapine-treated patients. Br J Psychiatry 1992;160:30-33.

26. Farde L, Nordstrom AL, Wiesel FA, Pauli S, Halldin C, Sedvall G. PET analysis of central D1 and D2 dopamine receptor occupancy in patients treated with chemical neuroleptics and clozapine: Relation to extra-pyramidal side effects. Arch Gen Psychiatry 1992;49:538-544.

27. Farde L, Wiesel FA, Stone-Elander S, et al. D2 dopamine receptors in neuroleptic-naive schizophrenic patients: a positron emission tomography study with 11C raclopride. Arch Gen Psychiatry 1990;47:213-219.

28. Farde L, Wiesel FA, Halldin C, Sedvall G. Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs. Arch Gen Psychiatry 1988;45:71-76.

29. Farde L. Selective D1- and D2-dopamine receptor blockade both induces akathisia in humans—a PET study with [11C]SCH 23390 and [11C]raclopride. Psychopharmacology 1992;107:23-29.

30. Frith CD, Friston KJ, Herold S, et al. Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. Br J Psychiatry 1995;167:343-349.

31. Gur RC, Erwin RJ, Gur RE. Neurobehavioral probes for physiologic neuroimaging studies. Arch Gen Psychiatry 1992;49:409-414.

32. Gur RC, Gur RE, Skolnick BE, et al. Effects of task difficulty on regional cerebral blood flow: relationships with anxiety and performance. Psychophysiology 1988;25:392-399.

33. Gur RC, Gur RE, Obrist WD, et al. Sex and handedness differences in cerebral blood flow during rest and cognitive activity. Science 1982;217:659-661.

34. Gur RC, Jaggi JL Ragland, et al. Effects of memory processing on regional brain activation: Cerebral blood flow in normal subjects. Int J Neurosci 1993;72:31-44.

35. Gur RE, Gur RC, Skolnick BE, et al. Brain function in psychiatric disorders: III. Regional cerebral blood flow in unmedicated schizophrenics. Arch Gen Psychiatry 1985;42:329-334.

36. Gur RE, Gur RC. Neurotransmitters are important, but so is metabolism. Neuropsychopharmacology 1992;7:63-65.

37. Gur RE, Mozley PD, Resnick SM, et al. Resting cerebral glucose metabolism and clinical features of schizophrenia. Arch Gen Psychiatry 1995;52:657-667.

38. Gur RE, Pearlson GD. Neuroimaging in schizophrenia research. Schizophr Bull 1993;19:337-353.

39. Gur RE, Resnick SM, Alavi A, et al. Regional brain function in schizophrenia. I. A positron emission tomography study. Arch Gen Psychiatry 1987;44:119-25.

40. Gur RE, Resnick SM, Gur RC. Laterality and frontality of cerebral blood flow and metabolism in schizophrenia: relationship to symptom specificity. Psychiatry Res 1989;27:325-34.

41. Gur RE, Resnick SM, Gur RC, et al. Regional brain function in schizophrenia. II. Repeated evaluation with positron emission tomography. Arch Gen Psychiatry 1987;44:126-129.

42. Gur RE, Skolnick BE, Gur RC, et al. Brain function in psychiatric disorders: I. Regional cerebral blood flow in medicated schizophrenics. Arch Gen Psychiatry 1983;40:1250-1254.

43. Gur RE. Left hemisphere dysfunction and left hemisphere overactivation in schizophrenia. J Abnorm Psychol 1978;87:226-238.

44. Holcomb HH, Cascella NG, Thaker GK, Medoff DR, Dannals RF, Tamminga CA. Functional sites of neuroleptic drug action in the human brain: PET/FDG studies with and without haloperidol. Am J Psychiatry 1996;153:41-49.

45. Ingvar DH, Franzen G. Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr Scand 1974;50:425-462.

46. Kapur S, Remington G, Jones C, et al. High levels of dopamine D2 receptor occupancy with low-dose haloperidol treatment: A PET study. Am J Psychiatry 1996;153:948-950.

47. Kapur S, Remington G, Zipursky RB, Wilson AA, Houle S. The D2 dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms: A PET study. Life Sci 1995;57:103-107.

48. Kawasaki Y, Maeda Y, Suzuki M, et al. SPECT analysis of rCBF changes during Wisconsin Card Sorting Test. Biol Psychiatry 1991;29:333S-701S.

49. Kawasaki Y, Maeda Y Suzuki M, et al. SPECT analysis of regional cerebral blood flow changes in patients with schizophrenia during the Wisconsin Card Sorting Test. Schizophr Res 1993;10:109-116.

50. Kessler RM, Ansari MS, Schmidt DE, et al. High affinity dopamine D2 receptor radioligands. 2. [125I]epidepride, a potent and specific radioligand for the characterization of striatal and extrastriatal dopamine D2 receptors. Life Sci 1991;49:617-628.

51. Kling AS, Metter EJ, Riege WH, Kuhl DE. Comparison of PET measurement of local brain glucose metabolism and CAT measurement of brain atrophy in chronic schizophrenia and depression. Am J Psychiatry 1986;143:175-180.

52. Konig P, Benzer MK, Fritzsche H. SPECT technique for visualization of cerebral dopamine D2 receptors. Am J Psychiatry 1991;148:1607-1608.

53. Kotrla KJ, Weinberger DR. Brain imaging in schizophrenia. Ann Rev Med 1995;46:113-122.

54. Liddle PF, Friston KJ, Frith CD, Hirsch SR, Jones T, Frackowiak RSJ. Patterns of cerebral blood flow in schizophrenia. Br J Psychiatry 1992;160:179-186.

55. Lieberman JA, Koreen AR. Neurochemistry and neuroendocrinology of schizophrenia: A selective review. Schizophr Bull 1993;19:371-429.

56. Martinot JL, Paillere-Martinot ML, Loc'h C, et al. The estimated density of D2 striatal receptors in schizophrenia: a study with positron emission tomography and 76Br-bromolisuride. Br J Psychiatry 1991;158:346-350.

57. Martinot JL, Peron-Magnan P, Huret JD, et al. Striatal D2 dopaminergic receptors assessed with positron emission tomography and [76Br]bromospiperone in untreated schizophrenic patients. Am J Psychiatry 1990;147:44-50.

58. Mathew RJ, Wilson WH, Tant SR, Robinson L, Prakash R. Abnormal resting regional cerebral blood flow patterns and their correlates in schizophrenia. Arch Gen Psychiatry 1988;45:542-549.

59. McGuire PK, Silbersweig DA, Wright I, et al. Abnormal monitoring of inner speech: a physiological basis for auditory hallucinations. Lancet 1995;346:596-600.

60. Mozley LH, Gur RC, Gur RE, Mozley PD, Alavi A. The relationship between verbal memory performance and the cerebral distribution of FDG in patients with schizophrenia. Biol Psychiatry 1996;40:443-451.

61. Mozley PD, Stubbs JB, Kung HF, Selikson MH, Stabin MG, Alavi A. Biodistribution and dosimetry of I-123 IBF: A potent SPECT radioligand for imaging the D2 dopamine receptor. J Nucl Med 1993;34:1910-1917.

62. Mozley PD, Zhu X, Kung HF, et al. The dosimetry of I-123 labeled TISCH: A SPECT imaging agent for the D1 dopamine receptor. J Nucl Med 1993;34:208-213.

63. Musalek M, Podreka I, Walter H, et al. Regional brain function in hallucinations: A study of regional cerebral blood flow with 99m-Tc-HMPAO-SPECT in patients with auditory hallucinations, tactile hallucinations, and normal controls. Compr Psychiatry 1989;30:99-108.

64. Nordstrom AL, Farde L, Eriksson L, Halldin C. No elevated D2 dopamine receptors in neuroleptic-naive schizophrenic patients revealed by positron emission tomography and [11C]N-methylspiperone. Psychiatry Res 1995;61:67-83.

65. Nordstrom AL, Farde L, Wiesel FA, et al. Central D2-dopamine receptor occupancy in relation to antipsychotic drug effects: A double-blind PET study of schizophrenic patients. Biol Psychiatry 1993;33:227-235.

66. O'Leary DS, Andreasen NC, Hurtig RR, et al. Auditory attentional deficits in patients with schizophrenia. A positron emission tomography study. Arch Gen Psychiatry 1996;53:633-641.

67. Pearlson GD, Tune LE, Wong DF, et al. Quantitative D2 dopamine receptor PET and structural MRI changes in late-onset schizophrenia. Schizophr Bull 1993;19:783-795.

68. Pilowsky LS, Costa DC, Ell PJ, Verhoeff NP, Murray RM, Kerwin RW. D2 dopamine receptor binding in the basal ganglia of antipsychotic-free schizophrenic patients. An 123I-IBZM single photon emission computerised tomography study. Br J Psychiatry 1994;164:16-26.

69. Renshaw PF, Yurgelun-Todd DA, Cohen BM. Greater hemodynamic response to photic stimulation in schizophrenic patients: An echo planar MRI study. Am J Psychiatry 1994;151:1493-1495.

70. Rubin P, Holm S, Friberg L, et al. Altered modulation of prefrontal and subcortical brain activity in newly diagnosed schizophrenia and schizophreniform disorder: a regional cerebral blood flow study. Arch Gen Psychiatry 1991;48:987-995.

71. Rubin P, Holm S, Friberg L, et al. rCBF (SPECT) and CT measurements during first episode schizophrenia and schizophreniform psychosis. Biol Psychiatry 1991;29:270.

72. Rubin P, Holm S, Madsen PL, et al. Regional cerebral blood flow distribution in newly diagnosed schizophrenia and schizophreniform disorder. Psychiatry Res 1994;53:57-75.

73. Saykin AJ, Gur RC, Gur RE, et al. Neuropsychological function in schizophrenia: selective impairment in memory and learning. Arch Gen Psychiatry 1991;48:618-624.

74. Schlyer DJ, Voklow ND, Fowler JD, et al. Regional distribution and kinetics of haloperidol binding in human brain: A PET study with [18F]haloperidol. Synapse 1992;11:10-19.

75. Sedvall G, Farde L, Persson A, Weisel FA. Imaging of neurotransmitter receptors in the living human brain. Arch Gen Psychiatry 1986;3:995-1005.

76. Sedvall GC. The current status of PET scanning with respect to schizophrenia. Neuropsychopharmacology 1992;7:41-54.

77. Sheppard G, Gruzelier J, Manchanda R, et al. 15-O positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients. Lancet 1983;2:1448-1452.

78. Siegel BV, Buchsbaum MS, Bunney WE, Jr, et al. Cortical-striatal-thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenic patients. Am J Psychiatry 1993;150:1325-1336.

79. Tamminga CA, Thaker GK, Buchanan R, et al. Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome. Arch Gen Psychiatry 1992;49:522-530.

80. Vita A, Bressi S, Perani D, et al. High-resolution SPECT study of regional cerebral blood flow in drug-free and drug-naive schizophrenic patients. Am J Psychiatry 1995;152:876-882.

81. Vita A, Giobbo GM, Dieci M, Garbarini M, Castignoli G, Invernizzi G. Frontal lobe dysfunction in schizophrenia: Evident from neuropsychological testing and brain imaging techniques. Biol Psychiatry 1991;29:647-S.

82. Volkow ND, Wolf AP, Van Gelder, et al. Phenomenological correlates of metabolic activity in 18 patients with chronic schizophrenia. Am J Psychiatry 1987;144:151-158.

83. Volkow ND, Wolf AP, Brodie JD, et al. Brain interactions in chronic schizophrenics under resting and activation conditions. Schizophr Res 1988;1:47-53.

84. Wagner HN, Burns HD, Dannals RF, et al. Imaging dopamine receptors in the human brain by positron emission tomography. Science 1983;221:1264-1266.

85. Warach S, Gur RC, Gur RE, Skolnick BE, Obrist WD, Reivich M. The reproducibility of the Xe-133 inhalation technique in resting studies: task order and sex related effects in healthy young adults. J Cereb Blood Flow and Metab 1987;7:702-708.

86. Weinberger DR, Berman KF, Illowsky B. Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. III. A new cohort and evidence for a monoaminergic mechanism. Arch Gen Psychiatry 1988;45:609-615.

87. Weinberger DR, Berman KF, Suddath R, Torrey EF. Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: A magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins. Am J Psychiatry 1992;149:890-897.

88. Weinberger DR, Berman KF, Zec RF. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch Gen Psychiatry 1986;43:114-125.

89. Wenz F, Schad LR, Knopp MV, et al. Functional magnetic resonance imaging at 1.5 T: Activation pattern in schizophrenic patients receiving neuroleptic medication. Mag Res Imaging 1994;12:975-982.

90. Wiesel FA, Wiik G, Sjogren I, Blomqvist G, Greitz T, Stone-Elander S. Regional brain glucose metabolism in drug free schizophrenic patients and clinical correlates. Acta Psychiatr Scand 1987;76:628-641.

91. Wolkin A, Angrist B, Wolf A, et al. Low frontal glucose utilization in chronic schizophrenia: a replication study. Am J Psychiatry 1988;145:251-253.

92. Wolkin A, Barouche F, Wolf AP, et al. Dopamine blockade and clinical response: Evidence for two biological subgroups of schizophrenia. Am J Psychiatry 1989;146:905-908.

93. Wolkin A, Jaeger J, Brodie JD, et al. Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography. Am J Psychiatry 1985;142:564-571.

94. Wong DF, Wagner HN, Pearlson G, et al. Dopamine receptor binding of C-11-3-N-methylspiperone in the caudate in schizophrenia and bipolar disorder: a preliminary report. Psychopharmacol Bull 1985;21:595-598.

95. Wong DF, Wagner HN, Tune LE, et al. Positron emission tomography reveals elevated D2 receptors in drug-naive schizophrenics. Science 1986;239:1473-1624.

96. Wood F, Flowers DL. Hypofrontal vs. Hypo-Sylvian blood flow in schizophrenia. Schizophr Bull 1990;16:413-424.

97. Yurgelun-Todd DA, Waternaux CM, Cohen BM, Gurber SA, English CD Renshaw PF. Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production. Am J Psychiatry 1996;153:200-205.

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published 2000