Himmelhoch et

al. (44)

21 depressed

patients (13 BP,

11UP)

Tranycypromine (30 mg)

added to lithium; open

trial; ? duration

Recent (11) or past (8) trials TCA

16 of 21 (76%)

responders

Price et al. (82)

12 depressed

inpatients (6

psychotic UP, 2

BP)

Tranycypromine (30-60

mg) added to Li; open

crossover with blinded

rater; 4 or more weeks

Lithium added to

desipramine or

adinazolam or

bupropion

8 of 12 (67%)

responders

Georgotas et al.

(36)

20 depressed, UP

patients

Phenelzine (15-75 mg);

open crossover, 2-7

weeks

Imipramine 150-300 mg

or equivalent for 1-8

months

11 of 20 (55%)

responders

Nolen et al. (69)

26 depressed, UP

patients

Tranycypromine (82 mg)

or L-5HTP; open

randomized crossover,

4weeks

Imipramine > 150 mg or

equivalent followed

by trials oxaprotiline,

fluvoxamine, and

sleep deprivation

TRP: 7 of 14 (50%)

responders

(L-5HTP; 0 of 12

responders)

TRP > L-5HTP

Nolen et al. (67)

13 depressed, UP

patients

Tranycypromine (71 mg)

or nomifensine; double

blind randomized

crossover, 4 weeks

Imipramine > 150 mg

followed by trials of

oxaprotiline,

fluvoxamine, and

sleep deprivation

TRP; 4/8 (50%)

responders

nomifensine: 0/5

responders

TRP > NOM

Nolen et al. (70)

39 major depression

inpatients (31 UP,

8 BP)

Brofaramine (218 mg;

n = 22),

tranylcypromine

(85 mg; n = 17)

Prospective trial of

nortriptyline or

maprotiline

TRP 10/17 (59%)

BRO: 13/22

(59%) BRO

better tolerated

than TRP.

Ryan et al. (88))

23 major depression

adolescent

outpatients, ages

11-18

Phenelzine (n = 1 alone;

+ TCA, n = 7)

tranylcypromine (n = 3)

alone; + TCA, n = 12);

open trial; ? duration

Adequate doses of

TCAs for {ewc MVIMG, MVIMAGE,!greateq.bmp} 6 weeks

12 of 23 (56%)

responders

McGrath et al

(58)

46 depressed

outpatients, UP

(atypical)

depression

Phenelzine (60-90 mg);

double blind randomized

crossover, 6 weeks

Imipramine (200-300

mg)  for 6 weeks

31 of  46 (67%)

responders

PHZ > IMI

Thase et al.

(107)

42 patients

outpatients, UP

(atypical)

depression

Phenelzine (n = 4; 60 mg)

or tranylcypromine (38.5

mg); open crossover, 6

weeks

Imipramine (257 mg)

and interpersonal

psychotherapy

17 of 26 (65%)

responders

Thase et al.

(108)

12 patients with

anergic BP

depression

Tranylcypromine (30-60

mg), double blind,

randomized crossover, 6 weeks

Imipramine (242 mg/

day)

9 of 12 (75%)

responders

TRP > IMI