TABLE 4. Placebo-controlled studies of fluvoxamine

Study N Result
Placebo    
     
Conti et al. (Conti L, Dell'Osso LRF, Mussetti L, Cassano GB. Fluvoxamine maleate: double-blind clinical trial vs placebo in hospitalized depressed patients. Curr Ther Res 1988;43:468–480. )
    45
 FLV > PLC
     
Placebo + imipramine
     
  
 
     
  
Amin et al. (Amin MM, Anath JV, Coleman BS, et al. Fluvoxamine: antidepressant effect confirmed in a placebo controlled international study. Clin Neuropharmacol 1984;7(Suppl 1):317–318. )
    481
 FLV = IMI > PLC
Itil et al. (Itil TM, Shrivastava RK, Mukherjee S, Coleman BS, Michael ST: A double-blind placebo-controlled study of fluvoxamine and imipramine in out-patients with primary depression. Br J Clin Pharmacol 1983;15(Suppl 3):433–438. )
    69
 FLV < IMI > PLC
Lydiard et al. (Lydiard RB, Laird LK, Morton WA, et al. Fluvoxamine, imipramine and placebo in the treatment of depressed outpatients: effects on depression. Psychopharmacol Bull 1989;25:68–70. )
    52
 FLV = IMI = PLC
Feighner et al. (Feighner J, Boyer WF, Meredith CH, Hendrickson GG. A placebo-controlled inpatients comparison of fluvoxamine maleate and imipramine in major depression. Int Clin Psychopharmacol 1989;4:239–244. )
    86
 FLV > IMI = PLC
March et al. (March JS, Kobak KA, Jefferson JW. A double-blind, placebocontrolled trial of fluvoxamine versus imipramine in outpatients with major depression. J Clin Psychiatry 1990;51:200–202. )
    40
 FLV > PLC = IMI
     
Placebo + desipramine    
     
Roth et al. (Roth D, Mattes J, Sheenan KH, Sheenan DV. A double blind comparison of fuvoxamine, desipramine and placebo in out-patients with depression. Prog Neuropsychopharm Biol Psychiat 1990;14: 929–939. )
    90
 FLV = DMI >PLC

FLV, fluvoxamine; PLC, placebo; IMI, imipramine; DMI,

desipramine.

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published 2000