| Fluvoxamine | Fluoxetine | Paroxetine | Sertraline | |
| Relative Ki | 9.4 |
1.0 |
0.8 |
6.4 |
| Estimated K i | 8.31 |
0.88 |
0.71 |
5.66 |
| Plasma concentration (nM) | 300.0 |
660.0 |
130.0 |
65.0 |
| Liver: water partition ratio | 26.6 |
12.1 |
26.2 |
12.2 |
| Liver concentration (M) | 4.4 |
6.2 |
3.5 |
0.8 |
| Change in desipramine* * PK studies (AUC) |
14% |
380% to 640% |
327% to 421% |
0% to 37% |
* Above baseline
AUC = Area under curve
References: (45)
published 2000