FIG. 1

Schematic diagram of the two-compartment open model. It is assumed that intravenously-administered medications are given directly into the central compartment. Irreversible elimination (via hepatic biotransformation or renal excretion) only occurs via the central compartment; KE is the first-order elimination rate constant. Reversible distribution occurs between central and peripheral compartments, with first-order distribution rate constants of K12 and K21.

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published 2000