|
Line/species |
Selection phenotype |
Replicates?a |
Sourceb |
|
Withdrawal Seizure Prone/Resistant mice
(WSP/WSR) |
Handling-induced convulsions after
ethanol vapor inhalation |
Yes |
1 |
|
High/Low Ethanol Withdrawal mice
(HW/LW) |
Handling-induced convulsions after
ethanol vapor inhalation |
Yes |
2 |
|
Preferring/Nonpreferring rats (P/NP) |
Preference for drinking 10% ethanol |
No |
3 |
|
High/Low Alcohol Drinking rats (HAD/LAD) |
Preference for drinking 10% ethanol |
Yes |
3 |
|
ALKO Alcohol/Nonalcohol rats (AA/ANA) |
Preference for drinking 10% ethanol |
No |
4 |
|
Low/High ethanol consuming rats
(UChA/UChB) |
Preference for drinking 10% ethanol |
No |
5 |
|
Sardinian Preferring/Nonpreferring Rats
(sP/sNP) |
Preference for drinking 10% ethanol |
No |
6 |
|
High/Low Alcohol Preference mice
(HAP/LAP) |
Preference for drinking 10% ethanol |
Yes |
3 |
|
ALKO tolerant/nontolerant rats (AT/ANT) |
Ethanol impairment of tilting-plane
performance |
No |
7 |
|
Long/Short Sleep mice (LS/SS) |
Duration of loss of righting reflex
after ethanol |
No |
2 |
|
High/Low Alcohol Sensitive rats
(HAS/LAS) |
Duration of loss of righting reflex
after ethanol |
Yes |
7 |
|
COLD/HOT mice |
Acute ethanol hypothermia |
Yes |
1 |
|
FAST/SLOW mice |
Ethanol-stimulated open-field activity |
Yes |
1 |
|
High/Low Alcohol Functional Tolerance
mice (HAFT/LAFT) |
Acute ethanol functional tolerance on
stationary rod balancing |
Yes |
2 |
|
HIGH/LOW Analgesic Response mice
(HAR/LAR) |
Levorphanol analgesia in the hotplate
test |
No |
1 |
|
High/Low Stress-Induced Analgesia
(HA/LA) |
Analgesia induced by cold water swim
stress |
No |
8 |
|
Diazepam Sensitive/Resistant mice
(DS/DR) |
Diazepam-induced rotarod ataxia |
No |
1 |
|
Diazepam High/Low Responders (DHR/DHL) |
Diazepam-induced rotarod ataxia |
Yes |
1 |
|
High/Low Diazepam Sensitive mice |
Diazepam-induced loss of righting
reflex |
No |
9 |
|
Flinders Sensitive/Resistant rats
(FSL/FRL) |
Diisopropylflurophosphate hypothermia |
No |
10 |
|
Neuroleptic Responder/Nonresponder mice
(NR/NNR) |
Haloperidol-induced catalepsy |
Yes |
11 |
|
Taste Aversion Prone/Resistant rats
(TAP/TAR) |
Cyclophosphamide-induced conditioned
taste-aversions |
No |
12 |
|
Nicotine Activated/Depressed mice (NA/ND) |
Nicotine sensitive Y-maze activity and
body temperature |
Yes |
2 |
"Replicates" refers to the existence of genetically distinct duplicate selected lines. Thus, there are two WSP (WSP-1 and WSP-2) and two WSR (WSR-1 and WSR-2) lines. Adapted and updated from (26).
1. Animal Research Facility,
Research Service (151Z), VA Medical Center, Portland, OR, 97201 USA
2. Institute for Behavioral
Genetics, University of Colorado, Box 447, Boulder, CO, 80309 USA
3. Department of Medicine, Indiana
University, Emerson Hall 421, 545 Barnhill Drive, Indianapolis, IN, 46202 USA
4.
ALKO Research Laboratories, PO Box 350, SF-10100 Helsinki 10, Finland
5.
Departamento de Farmacologia, Universidad de Chile, PO Box 70.000,
Santiago 9, Chile
6. Department of Experimental
Biology, University of Cagliari, Via Palabanda 12, Cagliari, Italy 09123
7. Department
of Pharmacology (C-236), Univ. Colorado Health Sciences Ctr., 4200 E. Ninth
Avenue, Denver, CO, 80262 USA
8. Department of Psychology,
University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA
9. Department of Pharmacology,
Faculty of Medicine, National Univ. of Singapore, Singapore 0511
10. Center
for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina,
27514 USA
11. Department
of Psychiatry, State University of New York, Stony Brook, NY, 11794-8101 USA
12. Department
of Psychiatry and Health Behavior, Med. College of Georgia, Augusta, GA 30910,
USA
published 2000