FIG. 4

Left: Test for conditioned withdrawal in morphine-dependent rats. Values are mean SEM percentages of baseline rate of lever pressing/minute. Mean SEM pretreatment baseline response rates on the test day were as follows: paired group = 60.0 8.4, unpaired group = 74.7 8.1, saline controls = 95.1 8.7 lever presses/minute. Asterisks indicate results significantly different from the unpaired group and saline controls (p < 0.05). (, paired group; %unpaired group; n, saline controls). From Baldwin and Koob (1) with permission. Right: Test for conditioned withdrawal in postdependent rats. Values are mean SEM percentages of baseline rate of lever pressing/minute. Mean SEM pretreatment baseline response rates on the test day were as follows: paired group = 66.0 10.8, unpaired group = 81.9 9.3 lever presses/minute. Asterisks indicate results significantly different from the unpaired group (p < 0.05). (, paired group; %, unpaired group). From Baldwin and Koob (1) with permission.

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published 2000