FIG. 3
Intracranial self-stimulation thresholds following 0, 3, 6, 12, 24, and 48 hr of cocaine self-administration at several time points postcocaine (0, 1, 3, 6, 12, 24, 48, and 72 hr). The results are expressed as percent change from baseline threshold levels. The mean SEM baseline threshold for the experimental group was 37.414 2.516 mA and for the control group 35.853 3.078 mA. The asterisks indicate statistically significant differences (p < 0.05) between control and experimental groups with Dunnett's tests after a significant group spent x hours interaction in the ANOVA. From Markou and Koob (46) with permission.
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published 2000