The Psychopharmacology of Sexual Behavior

James G. Pfaus
Center for Studies in Behavioural Neurobiology
Department of Psychology
Concordia University
Montreal, Quebec
H3G 1M8, Canada.

and

Barry J. Everitt
Department of Experimental Psychology
University of Cambridge
Cambridge, CB2 3EB
United Kingdom.

Address for correspondence.

REFERENCES

1. Ahlenius S. Larsson K. Evidence for a unique pharmacological profile of 8-OH-DPAT by evaluation of its effects on male rat sexual behaviour. In: Dourish CT, Ahlenius S, Hutson PH, eds. Pharmacology of central 5-HT1A receptors. Chichester: Ellis Horwood, 1987;185198.

2. Argiolas A, Melis MR, Gessa GL. Intraventricular oxytocin induces yawning and penile erection in rats. Eur J Pharmacol 1985;117: 395396.

3. Argiolas A, Collu M, Gessa, GL, Melis MR, Serra G. The oxytocin antagonist d(CH2)5Tyr(Me)-Orn8-vasotocin inhibits male copulatory behavior in rats. Eur J Pharmacol 1988;149:389392.

4. Arletti R, Benelli A, Bertolini A. Oxytocin involvement in male and female sexual behavior. Ann NY Acad Sci 1992;652:180193.

5. Bancroft J. Human sexuality and its problems. 2nd ed. Edinburgh: Churchill Livingstone, 1989.

6. Baum MJ, Everitt BJ. Increased expression of c-fos in the medial preoptic area after mating in the male rat: role of afferent inputs from the medial amygdala and midbrain central tegmental field. Neuroscience 1992;50:627646.

7. Becker JB. Hormonal influences on extrapyramidal sensorimotor function and hippocampal plasticity. In: Becker JB, Breedlove SM, Crews D, eds. Behavioral endocrinology Cambridge, MA: MIT Press, 1992;325356.

8. Bitran D, Hull EM. Pharmacological analysis of male rat sexual behavior. Neurosci Biobehav Rev 1987;11:365389.

9. Blackburn JR, Pfaus JG, Phillips AG. Dopamine function in appetitive and defensive behaviors. Prog Neurobiol 1982;39:247279.

10. Caggiula AR, Herndon JG, Scanlon R, Greenstone D, Bradshaw W, Sharp D. Dissociation of active from immobility components of sexual behavior in female rats by central 6-hydroxydopamine: implications for CA involvement in sexual behavior and sensorimotor responsiveness. Brain Res 1979;172:505520.

11. Caldwell JD, Prange AJ, Pedersen CA. Oxytocin facilitates the sexual receptivity of estrogen-treated rats. Neuropeptides 1986;7: 175189.

12. Caldwell JD, Jirikowski, GF, Greer ER, Pedersen CA. Medial preoptic area oxytocin and female sexual receptivity. Behav Neurosci 1989;103:655662.

13. Carmichael MS, Humbert R, Dixen J, Palmisano G, Greenleaf W, Davidson JM. Plasma oxytocin increases in the human sexual response. J Clin Endocrinol Metab 1987;64:2731.

14. Clark JT, Smith ER, Davidson JM. Enhancement of sexual motivation in male rats by yohimbine. Science 1984;225:847849.

15. Clark JT, Smith ER, Davidson JM. Evidence for the modulation of sexual behavior by alpha adrenoceptors in male rats. Neuroendocrinology 1985;41:3643.

16. Damsma G, Pfaus JG, Wenkster D, Phillips AG, Fibiger HC. Sexual behavior increases dopamine transmission in the nucleus accumbens and striatum of male rats: comparison with novelty and locomotion. Behav Neurosci 1992;106:181191.

17. Etgen AM. Intrahypothalamic implants of noradrenergic antagonists disrupt lordosis behavior in female rats. Physiol Behav 1990;48:3136.

18. Everitt BJ, Fuxe K, Hokfelt T, Jonsson G. Role of monoamines in the control by hormones of sexual receptivity in the female rat. J Comp Physiol Psychol 1975;89:556572.

19. Everitt BJ. Sexual motivation: a neural and behavioural analysis of the mechanisms underlying appetitive and copulatory responses of male rats. Neurosci Biobehav Rev 1990;14:217232.

20. Everitt BJ. Neuroendocrine and psychological mechanisms underlying masculine sexual behaviour. In: Archer T, Hansen S, eds. Biological psychology: neuroendocrine axis. Hillsdale, New Jersey: Lawrence Erlbaum, 1991;111122.

21. Everitt BJ, Bancroft J. Of rats and men: the comparative approach to male sexuality. In: Bancroft J, Davis CM, Ruppel HJ Jr., eds. Annual review of sex research. Vol. II. Society for the Scientific Study of Sex, 1991;77118.

22. Fernandez-Guasti A, Larsson K, Beyer C. Potentiative action of a- and b-adrenergic receptor stimulation in inducing lordosis behavior. Pharmacol Biochem Behav 1985;22:613617.

23. Foreman MM, Hall JL. Effects of D2-dopaminergic receptor stimulation on the lordotic response of female rats. Psychopharmacology 1987;91:96100.

24. Grierson JP, James MD, Pearson JR, Wilson CA. The effect of selective D1 and D2 dopaminergic agents on sexual receptivity in the female rat. Neuropharmacology 1988;27:181189.

25. Hansen S, Harthon C, Wallin E, Löfberg L, Svensson K. Mesotelencephalic dopamine system and reproductive behavior in the female rat: effects of ventral tegmental 6-hydroxydopamine lesions on maternal and sexual responsiveness. Behav Neurosci 1991;105:588598.

26. Herbert J. Peptides in the limbic system: neurochemical codes for co-ordinated adaptive responses to behavioural and physiological demand. Prog Neurobiol 1993;41:723791.

27. Hillegart V. Functional topography of brain serotonergic pathways in the rat. Acta Physiol Scand 1991;142(Suppl 598):1180.

28. Hughes AM, Everitt BJ, Lightman SL, Todd K. Oxytocin in the central nervous system and sexual behavior in male rats. Brain Res 1987;41:133137.

29. Hughes AM, Everitt BJ, Herbert J. Selective effects of b-endorphin infused into the hypothalamus, preoptic area and bed nucleus of the stria terminalis on the sexual and ingestive behavour of male rats. Neuroscience 1987;23:10631073.

30. Hughes AM; Everitt BJ, Herbert J. The effects of simultaneous or separate infusions of some pro-opiomelanocortin-derived peptides (b-endorphin, melanocyte stimulating hormone and corticotrophin-like intermediate polypeptide) and their acetylated derivatives upon sexual and ingestive behavior of male rats. Neuroscience 1988; 2:689698.

31. Hughes AM, Herbert J, Everitt BJ. Comparative effects of preoptic area infusions of opioid peptides, lesions and castration on sexual behavior in male rats: studies of instrumental behavior, conditioned place preference and partner preference. Psychopharmacology 1990;102(2):243256.

32. Lal S, Ackman D, Tharundayil JX, Kiely ME, Etienne P. Effects of apomorphine, a dopamine receptor agonist, on penile tumescence in normal subjects. Prog Neurpsychopharmacol Biol Psychiatry 1984;8:695699.

33. Leyton M, Stewart J. The stimulation of central k-opioid receptors decreases male sexual behavior and locomotor activity. Brain Res 1992;594:5674.

34. Lindblom C, Forsberg G, Södersten P. The effect of naloxone on sexual behavior in female rats depends on the site of injection. Neurosci Lett 1987;70:97100.

35. McCarthy MM, Schwartz-Giblin S, Pfaff DW. Intracerebral administration of glutamic acid decarboxylase (GAD) antisense oligodeoxynucleotide reduces lordosis behavior in the rat. Soc Neurosci Abstr 1991;17:497.

36. McCarthy MM, Schlenker E, Pfaff DW. Neonatal intracerebral infusion of antisense DNA to estrogen receptor mRNA alters estrogen-dependent parameters in adult rats. Soc Neurosci Abstr 1992; 18:893.

37. McCarthy MM, Brooks PJ, Pfaus JG, et al. Antisense oligodeoxynucleotides in behavioral neuroscience. Neuroprotocols 1993;2:6774.

38. Malatesta VJ, Pollack RH, Wilbanks WA, Adams HE. Alcohol effects on the orgasmic-ejaculatory response in human males. J Sex Res 1979;15:101107.

39. Malatesta VJ, Pollack RH, Crotty TD, Peacock LJ. Acute alcohol intoxication and female orgasmic response. J Sex Res 1982;18:117.

40. Mas M, Gonzalez-Mora J, Louilot A, Sole C, Guadalupe T. Increased dopamine release in the nucleus accumbens of copulating male rats as evidenced by in vivo voltametry. Neurosci Lett 1990;110:303308.

41. Mehrara BJ, Baum MJ. Naloxone disrupts the expression but not the acquisition by male rats of a conditioned place preference response for an oestrous female. Psychopharmacology 1990;101: 118125.

42. Meisel RL, Cam DM, Robinson TE. A microdialysis study of ventral striatal dopamine during sexual behavior in female Syrian hamsters. Behav Brain Res 1990;55:151157.

43. Mendelson SD, Gorzalka BB. Stimulation of b-adrenoreceptors inhibits lordosis behavior in the female rat. Pharmacol Biochem Behav 1988;29:717723.

44. Mendelson SD, Pfaus JG. Level searching: a new assay of sexual motivation in the male rat. Physiol Behav 1989;45:337341.

45. Mendelson SD. A review and reevaluation of the role of serotonin in the modulation of lordosis behavior in the female rat. Neurosci Biobehav Rev 1992;16:309350.

46. Miller RL, Baum MJ. Naloxone inhibits mating and conditioned place preference for an estrous female in male rats soon after castration. Pharmacol Biochem Behav 1987;26:781789.

47. Mitchell JB, Gratton A. Opioid modulation and sensitization of dopamine release elicited by sexually relevant stimuli: a high-speed chronoamperometric study in freely-behaving rats. Brain Res 1991;551:2027.

48. Mitchell JB, Stewart J. Facilitation of sexual behaviors in the male rat associated with intra-VTA injections of opiates. Pharmacol Biochem Behav 1990;35:643650.

49. Mitchell JB, Stewart J. Facilitation of sexual behaviors in the male rat in the presence of stimuli previously paired with systemic injections of morphine. Pharmacol Biochem Behav 1990;35:367372.

50. Murmelstein PG, Becker JB. Increased extracellular dopamine in the nucleus accumbens and striatum of the female rat during paced copulatory behavior. J Neurosci [in press].

51. Ogawa S, Olazabel UE, Pfaff DW. Effects of hypothalamic administration of antisense DNA for progesterone receptor mRNA on lordosis behavior and progesterone receptor immunoreactivity. Soc Neurosci Abstr 1992;18:893.

52. Oldenburger WP, Everitt BJ, De Jonge FH. Conditioned place preference induced by sexual interaction in female rats. Horm Behav 1992;26:214228.

53. Pfaus JG, Gorzalka BB. Opioids and sexual behavior. Neurosci Biobehav Rev 1987;11:134.

54. Pfaus JG, Gorzalka BB. Selective activation of opioid receptors differentially affects lordosis behavior in female rats. Peptides 1987;8:309317.

55. Pfaus JG, Pinel JPJ. Alcohol inhibits and disinhibits sexual behavior in the male rat. Psychobiology 1989;17:195201.

56. Pfaus JG, Damsma G, Nomikos GG, et al. Sexual behavior enhances central dopamine transmission in the male rat. Brain Res 1990;530:345348.

57. Pfaus JG, Mendelson SD, Phillips AG. A correlational and factor analysis of anticipatory and consummatory measures of sexual behavior in the male rat. Psychoneuroendocrinology 1990;15:329340.

58. Pfaus JG, Phillips AG. Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat. Behav Neurosci 1991;105:727743.

59. Pfaus JG, Pfaff DW. m-, a-, and k-opioid receptor agonists selectively modulate sexual behaviors in the female rat: differential dependence on progesterone. Horm Behav 1992;26:457473.

60. Pfaus JG, Wenkstern D, Fibiger HC. Sexual activity increases dopamine transmission in the nucleus accumbens and striatum of female rats. [submitted].

61. Phillips AG, Pfaus JG, Blaha CD. Dopamine and motivated behavior: insights provided by in vivo analyses. In: Willner P, Scheel-Kruger J, eds. The mesolimbic dopamine system: from motivation to action. London: Wiley, 1991:199224.

62. Pinel JPJ, Pfaus JG. Effects of alcohol on the sexual behavior of female rats. Soc Neurosci Abstr 1988;14:41.

63. Pinel JPJ, Pfaus JG, Christensen BK. Contingent tolerance to the disruptive effects of alcohol on the copulatory behavior of male rats. Pharmacol Biochem Behav 1991;41:133137.

64. Pollio G, Xue P, Zanisi M, Nicolin A, Maggi A. Antisense oligonucleotide blocks progesterone-induced lordosis behavior in ovariectomized rats. Molec Brain Res 1993;19:135139.

65. Riley AJ, Goodman RE, Kellet JM, Orr R. Double-blind trial of yohimbine hydrochloride in the treatment of erection inadequacy. Sex Marital Ther 1989;4:1726.

66. Robbins TW, Everitt BJ. Functional studies of the central catecholamines. Int Rev Neurobiol 1982;23:303365.

67. Rosen RC. Alcohol and drug effects on sexual response: human experimental and clinical studies. In: Bancroft J, Davis CM, Ruppel HJ Jr. Annual Review of Sex Research. Vol. II. Society for the Scientific Study of Sex, 1991:119180.

68. Sachs BD, Meisel RL. The physiology of male sexual behavior. In: Knobil E, Neill J. et al. eds. The physiology of reproduction. New York: Raven Press, 1988:13931486.

69. Schumacher M, Coirini H, Pfaff DW, McEwen BS. Behavioral effects of progesterone associated with rapid modulation of oxytocin receptors. Science 1990;250:691694.

70. Schulze HG, Gorzalka BB. Oxytocin effects on lordosis frequency and lordosis duration following infusion into the medial pre-optic area and ventromedial hypothalamus of female rats. Neuropeptides 1991;18:99106.

71. Sirinathsinghji DJS. Modulation of lordosis behavior of female rats by naloxone, b-endorphin, and its antiserum in the mesencephalic central grey: possible mediation via GnRH. Neuroendocrinology 1984;39:222230.

72. Stavy M, Herbert J. Differential effects of b-endorphin infused into the hypothalamic preoptic area at various phases of the male rat's sexual behavior. Neuroscience 198;30:433442.

73. Stoneham MD, Everitt BJ, Hansen S, Lightman SL, Todd K. Oxytocin and sexual behavior in the male rat and rabbit. J Endocrinol 1985;107:97106.

74. Susset JG, Tessier CD, Wincze J, Bansal S, Malhotra C, Schwacha MG. Effect of yohimbine hydrochloride on erectile impotence: a double-blind study. J Urol 1989;141:13601363.

75. Vathy I, van der Plas J, Vincent PA, Etgen AM. Intracranial dialysis and microinfusion studies suggest that morphine may act in the ventromedial hypothalamus to inhibit female sexual behavior. Horm Behav 1991;25:354366.

76. Ware JC, Pittard JT, Nadig PW, Morrison JL, Quinn JB. Trazodon: its effects on nocturnal penile tumescence. Sleep Res 1987;16:157.

77. Wiesenfeld-Hallin Z, Södersten P. Spinal opiates affect sexual behavior in rats. Nature 1984;309:257258.

78. Wenkstern D, Pfaus JG, Fibiger HC. Dopamine transmission increases in the nucleus accumbens of male rats during their first exposure to sexually receptive female rats. Brain Res 1993;618:4146.

79. Wiesner JB, Moss RL. A psychopharmacological characterization of the opioid suppression of sexual behaviour in the female rat. In: Dyer RG, Bicknell RJ, eds. Brain opioid systems in reproduction. Oxford: Oxford University Press; 1989:187202.

80. Williams JR, Carter CS. Oxytocin inhibited sexual behavior and facilitated social behavior in male prarie voles. 18th annual conference on reproductive behavior, Atlanta. 1990.

81. Witt DM, Carter CS, Walton DM. Central and peripheral effects of oxytocin administration in prarie voles (Microtus ochrogaster). Pharmacol Biochem Behav 1990;37:6369.

Back to Chapter

 

published 2000