Neuroendocrine Interactions

Bruce S. McEwen
Rockefeller University
1230 York Avenue, Box 165
New York, New York 10021
Tel: (212) 327-8624
Fax: (212) 327-8634


1.  McEwen BS, Stellar E. Stress and the Individual: Mechanisms leading to disease. Archives of Internal Medicine 1993;153:2093-2101.

2.  Miner JN, Yamamoto KR. Regulatory crosstalk at composite response elements. Trends in Biochem Sci 1991;16:423-426.

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5.  Baulieu EE. Neurosteroids: a function of the brain. In: Costa E, Paul SM, eds. Neurosteroids and Brain Function. New York: Thieme, 1991:63-73.

6.  McEwen BS. Non-genomic and genomic effects of steroids on neural activity. TIPS 1991;112:141-147.

7.  Gee KW. Steroid modulation of the GABA/Benzodiazepine receptor-linked chloride lonophore. Molecular Neurobiology 1988;2:291-317.

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9.  Orchinik M, Murray TF, Franklin PH, Moore FL. Guanyl nucleotides modulate binding to steroid receptors in neuronal membranes. Proc  Natl  acad  Sci  USA 1992;89:3830

10.  Blackmore PF, Neulen J, Lattanzio F, Beebe SJ. Cell surface-binding sites for progesterone mediate calcium uptake in human sperm. J Biol Chem 1990;199:1266:18655

11.  Wehling M, Christ M, Thiesen K. Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action. Am  J  Physiol 1992;263:E974

12.  Wong M, Moss RL. Long-term and short-term electrophysiological effects of estrogen on the synaptic properties of hippocampal CA1 neurons. The Journal of Neuroscience 1992;12:3217-3225.

13.  McEwen BS, Alves SH. Estrogens: Non-reproductive actions in the brain. Endocrine Rev 1998;

14.  Erulkar SD, Wetzel DM. 5 alpha dihydrotestosterone has nonspecific effects on membrane channels and possible genomic effects on ACh-activated channels. J  Neurophysiol 1989;61:1036-1052.

15.  Rendt JM, Toro L, Stefani E, Erulkar SD. Progesterone increases Ca currents in myometrial cells from immature and nonpregnant adult rats. Am  J  Physiol 1992;262:C293-C301.

16.  Toro L, Stefani E, Erulkar SD. Hormonal regulation of potassium currents in single myometrial cells. Proc  Natl  acad  Sci  USA 1990;87:2892-2895.

17.  Joels M, DeKloet ER. Control of neuronal excitability by corticosteroid hormones. Trends in Neurosci 1992;15:25-30.

18.  McEwen BS, Cameron H, Chao H, Gould E, Luine V, et al. Resolving a mystery: progress in understanding the function of adrenal steroid receptors in hippocampus. Prog Brain Res 1994;100:149-157.

19.  Pfaff DW. Estrogens and Brain Function. New York: Springer-Verlag, 1980;-281.

20.  McEwen BS. Our changing ideas about steroid effects on an ever-changing brain. Seminars in Neurosciences 1991;3:497-507.

21.  McEwen BS, Jones K, Pfaff D. Hormonal control of sexual behavior in the female rat: molecular, cellular and neurochemical studies. Biol Reprod 1987;36:37-45.

22.  Frankfurt M, Gould E, Wolley C, McEwen BS. Gonadal steroids modify dendritic spine density in ventromedial hypothalamic neurons: a golgi study in the adult rat. Neuroendo 1990;51:530-535.

23.  Schumacher M, Coirini H, Pfaff D, McEwen BS. Behavioral effects of progesterone associated with rapid modulation of oxytocin receptors. Science 1990;250:691-694.

24.  McEwen BS, Biegon A, Davis P, et al. Steroid hormones: humoral signals which alter brain cell properties and functions. In: AnonymousRecent Progress in Hormone Research. New York: Academic Press, 1982:41-92.

25.  Frye CA, Gardiner SG. Progestins can have a membrane-mediated action in rat midbrain for facilitation of sexual receptivity. Horm Behav 1996;30:682-691.

26.  Flanagan L, Pfaus J, Pfaff D, McEwen BS. Induction of FOS immunoreactivity in oxytocin neurons after sexual activity in female rats. Neuroendo 1993;58:352-358.

27.  Parsons B, McEwen BS. Sequential inhibition of sexual receptivity by progesterone is not related to decreased hypothalamic progestin receptors in the female rat. J Neurosci 1981;1:527-531.

28.  Woolley C, McEwen BS. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol 1993;336:293-306.

29.  Stephan F. Coupling between feeding-and light-entrainable circadian pacemakers in the rat. Physiol Behav 1986;38:537-544.

30.  McEwen BS, Angulo J, Cameron H, Chao H, Daniels D, et al. Paradoxical effects of adrenal steroids on the brain: protection versus degeneration. Biol.Psych. 1992;31:177-179.

31.  McEwen BS, Sakai RR, Spencer RL. Adrenal steroid effects on the brain: versatile hormones with good and bad effects. In: Schulkin J, ed. Hormonally-Induced Changes in Mind and Brain. San Diego: Academic Press, 1993:157-189.

32.  Diamond DM, Bennett MC, Fleshner M, Rose GM. Inverted-U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation. Hippocampus 1992;2:421-430.

33.  Rasika S, Nottebohm F, Alvarez-Buylla A. Testosterone increases the recruitment and/or survival of new high vocal center neurons in adult female canaries. Proc  Natl  acad  Sci  USA 1994;91:7854-7858.

34.  Calof AL, Hagiwara N, Holcomb JD, Mumm JS, Shou J. Neurogenesis and cell death in olfactory epithelium. J  Neurobiol 1996;30:67-81.

35.  Lim DA, Fishell GJ, Alvarez-Buylla A. Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis. Proc  Natl  acad  Sci  USA 1997;94:14832-14836.

36.  Goldman SA, Luskin MB. Strategies utilized by migrating neurons of the postnatal vertebrate forebrain. Trends in Neuroscience 1998;21:107-114.

37.  McEwen BS. Stress, sex, hippocampal plasticity: Implications for psychiatric illness. blank for now 1998;

38.  Eriksson PS, Permlieva E, Bjork-Eriksson T, Alborn A-M, Nordborg C, et al. Neurogenesis in the adult human hippocampus. Nature Medicine 1998;4:1313-1317.(Abstract)

39.  Gould E, McEwen BS. Neuronal birth and death. Current Opinion in Neurobiology 1993;3:676-682.

40.  Sherry DF, Jacobs LF, Gaulin SJC. Spatial memory and adaptive specialization of the hippocampus. TINS 1992;15:298-303.

41.  McEwen BS. Re-examination of the glucocorticoid cascade hypothesis of stress and aging. In: Swaab D, Hoffman M, Mirmiran R, Ravid F, van Leeuwen F, eds. Progress in Brain Research. Amsterdam: Elsevier, 1992:365-383.

42.  Joels M, DeKloet ER. Control of neuronal excitability by corticosteroid hormones. TINS 1992;15:25-30.

43.  Sapolsky R. Stress, the Aging Brain and the Mechanisms of Neuron Death. Cambridge MIT Press 1992;1:423

44.  Manuck SB, Kapley JR, Adams MR, Clarkson TB. Studies of psychosocial influences on coronary artery atherosclerosis in cynomolgus monkey. Health Psychol 1988;7:113-124.

45.  Pouliot wA, Handa RJ, Beck SG. Androgen Modulates N-Methyl-D-Aspartate-mediated Depolarization in CA1 Hippocampal Pyramidal Cells. Synapse 1996;23:10-19.

46.  Woolley C, McEwen BS. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. Journal Neuroscience 1992;12:2549-2554.

47.  McEwen BS. Possible mechanisms for atrophy of the human hippocampus. Molecular Psychiatry 1997;2:255-262.

48.  Weiner H. Perturbing the Organism: The Biology of Stressful Experiences. Chicago, IL: University of Chicago Press, 1992;357pp

49.  McEwen BS. Protective and Damaging Effects of Stress Mediators. New England J Med 1998;338:171-179.

50.  Munck A, Guyre PM, Holbrook NJ. Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions. Endocrine Review 1984;5:25-43.

51.  Pacak K, Kvetnansky R, Palkovits M, Fukuhara K, Yadid G, et al. Adrenalectomy augments in vivo release of norepinephrine in the paraventricular nucleus during immobilization stress. Endocrinology 1993;133:1404-1410.

52.  Rubinow DR. The premenstrual syndrome: New views. JAMA 1992;268:1908-1912.

53.  Stone E, McEwen BS, Herrera A, Carr K. Regulation of a and b components of noradrenergic cyclic AMP response in cortical slices. Eur.J.Pharm. 1987;141:347-356.

54.  Kuroda Y, Mikuni M, Ogawa T, Takahashi K. Effect of ACTH, adrenalectomy and the combination treatment on the density of 5-HT2 receptor binding sites in neocortex of rat forebrain and 5-HT2 receptor-mediated wet-dog shake behaviors. Psychopharmacology 1992;108:27-32.

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56.  Swanson L, Simmons DM. Differential steroid hormone and neural influences on peptide mRNA levels in CRH cells of the paraventricular nucleus: a hybridization histochemical study in the rat. Journal Comp Neurol 1989;285:413-435.

57.  Azmitia E, McEwen BS. Adrenocortical influence on rat brain tryptophan hydroxylase activity. Brain Res 1974;78:291-302.

58.  Paul SM, Purdy RH. Neuroactive steroids. FASEB Journal 1992;6:2311-2322.

59.  Edwards E, Harkins K, Wright G, Henn F. Effects of bilateral adrenalectomy on the induction of learned helplessness behavior. Neuropsychopharmacology 1990;3:109-114.

60.  Sterling P, Eyer J. Allostasis: A New Paradigm to Explain Arousal Pathology. In: Fisher S, Reason J, eds. Handbook of Life Stress, Cognition and Health. New York: John Wiley & Sons, 1988:629-649.

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62.  Manuck SB, Kaplan JR, Muldoon MF, Adams MR, Clarkson TB. The behavioral exacerbation of atherosclerosis and its inhibition by propranolol. In: McCabe PM, Schneiderman N, Field TM, Skyler JS, eds. Stress, Coping And Disease. Hove and London: Lawrence Erlbaum Associates, 1991:51-72.

63.  Gould E, Woolley C, McEwen BS. The hippocampal formation: morphological changes induced by thyroid, gonadal and adrenal hormones. Psychoneuroendocrinology 1991;16:67-84.

64.  Westlind-Danielsson A, Gould E, McEwen BS. Thyroid hormone causes sexually distinct neurochemical and morphological alterations in rat septal-diagonal band neurons. J Neurochem 1991;56:119-128.

65.  Pavlides C, Westlind-Danielsson A, Nyborg H, McEwen BS. Neonatal hyperthyroidism disrupts hippocampal LTP and spatial learning. Exp Brain Res 1991;85:559-564.

66.  Schwegler H, Crusio WE, Lipp HP, Brust I, Mueller GG. Early postnatal hyperthyroidism alters hippocampal circuitry and improves radial-maze learning in adult mice. J Neurosci 1991;11:2102-2106.

67.  Adkins-Regan E. Early organizational effects of hormones. Neuroendocrinology of Reproduction 1981;159-228.

68.  McEwen BS. Actions of sex hormones on the brain: "organization" and "activation" in relation to functional teratology. In: Boer G, Feenstra M, Mirmiran M, Swaab D, Van Haaren F, eds. Progress in Brain Research, Vol. 73. Amsterdam: Elsevier, 1988:121-134.

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76.  Allen LS, Richey MF, Chai YM, Gorski RA. Sex differences in the Corpus Callosum of the Living Human Being. The Journal of Neuroscience 1991;11:933-942.

77.  Allen L, Gorski R. Sexual dimorphism of the anterior commissure and massa intermeida of the human brain. Journal Comp Neurol 1991;312:97-104.

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79.  Hier D. Sex differences in hemispheric specialization: hypothesis for the excess of dyslexia in boys. Bull Orton Soc 1979;29:74-83.

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82.  Uno H, Ross T, Else J, Suleman M, Sapolsky R. Hippocampal damage associated with prolonged and fatal stress in primates. J Neurosci 1989;9:1709-1711.

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88.  Bonuccelli U, Melis GB, Paoletti AM, Fioretti P, Murri L, et al. Unbalanced progesterone and estradiol secretion  in catamenial epilepsy. Epilepsy Research 1989;3:100-106.

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90.  DeVane GW. Editorial: Premenstrual Syndrome. J Clin Endocrinol Metab 1991;72:250-251.

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94.  Seeman MV, Lang M. The role of estrogens in schizophrenia gender differences. Schizophrenia Bull 1990;16:185-194.

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published 2000