Table 1.   Human Adenosine Receptor Subtypes

Name

GenBank

Accession #

Transductional

System

Agonists

Antagonists

A₁

P30542

Decrease cAMP

Increase IP₃

CCPA,

CPA,

CHA

CPX,

KFM 19

A_2A

P29274

Increase cAMP

CGS 21680

SCH 58261,

ZM 241385,

CSC,

KF 17837

A_2B

P29275

Increase cAMP

NECA

CGS 15943A,

Enprophylline,

CPX

A₃

P22765

Decrease cAMP

IB-MECA

Cl-IB-MECA

MRS 1191,

MRS 1067,

L-249313,

L-268605