| TABLE 2. Various endocrine therapies in clinically metastatic
breast cancer: response rates in unselected patients |
|
Therapy
|
No. of Patients
|
Response rate (%)
|
Range (%)
|
Effective in
|
|
Tamoxifen
|
1269
|
32
|
16-52
|
Pre- and postmenopause
|
|
Oophorectomy
|
3380
|
33
|
21-41
|
Premenopause or within 1 year from last menstrual period
|
|
Progestins
|
3479
|
31
|
9-67
|
Pre- and postmenopause
|
|
Aminoglutethimide
|
1153
|
32
|
16-43
|
Postmenopause
|
|
LHRH analogs
|
293
|
40
|
32-45
|
Premenopause
|
|
Estrogens
|
1683
|
26
|
15-38
|
Postmenopause
|
|
Androgens
|
2250
|
21
|
10-38
|
Pre- and postmenopause
|
|
Adrenalectomy
|
3739
|
32
|
23-46
|
Pre- and postmenopause
|
|
Hypophysectomy
|
1174
|
36
|
22-58
|
Pre- and postmenopause
|
|
| (From reference (101), reproduced
with permission) |
| Back to Chapter
|