Galanin, A Neuropeptide with Important Central Nervous System Actions / Table 2

TABLE 2. Galanin receptor antagonists reverse the effects of galanin upon i.cv, PVN, or in vitro application a

	Galanin effects reversed
Antagonist	Lowered spinal excitability	Inhibition of insulin release	Stimulation of feeding	Cognitive impairment	Inhibition of ACh release	Stimulation of growth hormone release	Stimulation of prolactin release	Vagal attenuation
M15	+ +	+ +	+ +	nt	+ +	+ +	+	+ +
M35	+ +	+ +	+	+	+ +	nt	nt
M40	+	No effect	+ +		+ +	nt	nt

a Some data are from ref. (6).nt, not tested. + +, reversal of galanin effect at equimolar dose. +, reversal of galanin effect at 10-fold or higher excess of the antagonist.

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published 2000