Figure 1.

FIG. 1. Schematic representation of the three known transduction pathways for 5-HT1 receptors: an increase in an inwardly rectifying K+ current (IK); a decrease in a high threshold Ca2+ current (ICa(ht)); and inhibition of adenylyl cyclase (A-cyc). All of these actions are mediated through the pertussis-toxin-sensitive G proteins Gi and/or Go. Although Gi has traditionally been regarded as the G protein that couples to adenylyl cyclase, recent evidence indicates that the form of Go which is found in the brain also couples negatively to adenylyl cyclase (17).

Back To Chapter

published 2000