|
TABLE 1. Major signal transduction pathways for
serotonin receptors
|
|
Receptor
|
|
|
|
subtype
|
G protein
|
Effector pathway
|
|
5-HT1A
|
Gi
|
Inhibition of adenylate cyclase
|
| |
Gi
|
Opening of K+ channel
|
| |
Go
|
Closing of Ca2+ channel
|
|
5-HT1B
|
Gi
|
Inhibition of adenylate cyclase
|
|
5-HT1Da
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
|
5-HT1Db
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
|
5-HT1E
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
|
5-HT2Aa
|
Gqd
|
Phosphoinositide hydrolysis
|
|
5-HT2Bb
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
|
5-HT2Cc
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
|
5-HT3
|
No G protein
|
Ligand-gated ion channel
|
|
5-HT4
|
Gs
|
Activation of adenylate cyclase
|
|
5-HT6
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
|
|
Receptor
|
|
|
|
subtype
|
G protein
|
Effector pathway
|
|
5-HT1A
|
Gi
|
Inhibition of adenylate cyclase
|
| |
Gi
|
Opening of K+ channel
|
| |
Go
|
Closing of Ca2+ channel
|
|
5-HT1B
|
Gi
|
Inhibition of adenylate cyclase
|
|
5-HT1Da
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
|
5-HT1Db
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
|
5-HT1E
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
|
5-HT2Aa
|
Gqd
|
Phosphoinositide hydrolysis
|
|
5-HT2Bb
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
|
5-HT2Cc
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
|
5-HT3
|
No G protein
|
Ligand-gated ion channel
|
|
5-HT4
|
Gs
|
Activation of adenylate cyclase
|
|
5-HT6
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
{ewc MVIMG, MVIMAGE,!dnarrow.BMP}
|
|
|
a New nomenclature [Humphrey et al. (36)];
formerly 5- HT2.
|
|
b New nomenclature [Humphrey et al. (36)];
formerly 5- HT2F.
|
| c New nomenclature [Humphrey et al. (36)];
formerly 5- HT1C. |
| d The specific G-protein subtype has not been identified. |
| It is assumed that a member of the Gq family links
to PLC. |
| However, in some tissues, 5-HT2A-receptor-mediated
phos- phoinositide hydrolysis is pertussis-toxin-sensitive. |
| Back to Chapter
|