|
|
|
5-HT2A
|
5-HT2B
|
5-HT2C
|
|
|
[Ki (nM) or pA2 value using rat
fundus preparation]
|
|
Reference:
|
|
|
|
5-HT2A-preferring
|
|
|
Risperidone
|
|
0.4
|
29
|
64
|
(150)
|
|
Pirenperone
|
|
1.1
|
61
|
77
|
(150)
|
|
Spiperone
|
|
1.4
|
590
|
3,830
|
(68)
|
|
Ketanserin
|
|
2.0
|
395
|
160
|
(150)
|
|
MDL 11,939
|
|
6.1
|
3,020
|
1,020
|
(150)
|
|
AMI-193
|
|
7.7
|
710
|
8,495
|
(68)
|
|
|
|
5-HT2B-preferring
|
|
|
LY23728
|
|
66
|
pA2 = 9.17
|
123
|
(10)
|
|
LY266097
|
|
19
|
pA2 = 9.80
|
25
|
(10)
|
|
SB 204741
|
|
>10,000
|
79
|
2,000
|
(18)
|
|
|
|
5-HT2B/2C-preferring
|
|
|
SB 206553
|
|
1,600
|
pA2 = 8.48
|
10
|
(43)
|
|
SB 200646 A
|
|
>10,000
|
630
|
400
|
(18)
|
|
SDZ SER-082
|
|
630
|
pA2 = 7.34
|
16
|
(102)
|
|