|
Receptor
subtype
|
Number of
amino acids
|
Number of
introns
|
Second messenger
|
Species and references
|
|
5-HT1a
|
421 (human)
421 (rat)
|
0
|
cAMP , K+ channel,
IP3
|
Human (9), rat (3)
|
|
5-HT1b
|
390 (human)
386 (mouse)
|
0
|
cAMP
|
Human (1), mouse (28)
rat (48)
|
|
5-HT1d
|
377
|
0
|
cAMP
|
Human (16)
|
|
5-HT1e
|
365
|
0
|
cAMP
|
Human (24),30)
|
|
5-HT1f
|
366
|
0
|
cAMP
|
Human (2)
|
|
5-HT2a (5-HT2)a
|
471
|
3
|
IP3
|
Human (5,41),
rat (20,38)
mouse (52), hamster (47)
|
|
5-HT2b (5-HT2f)
|
479
|
<2
|
IP3
|
Rat (10,23)
|
|
5-HT2c (5-HT1c)
|
460 (rat, human)
459 (mouse)
|
3
|
IP3
|
Human (5), rat (19)
mouse (53)
|
|
5-HT5a
|
357
|
1
|
Unknown
|
Mouse (29,37)
|
|
5-HT5b
|
370
|
1
|
Unknown
|
Mouse (29)
|
|
5-HT6
|
437
|
<1
|
cAMP
|
Rat (32)
|
|
dro-1
|
564
|
0
|
cAMP
|
Drosophila (51)
|
|
dro-2a
|
834
|
0
|
cAMP , IP3
|
Drosophila (40)
|
|
dro-2b
|
645
|
4
|
cAMP , IP3
|
Drosophila (40)
|
|