|
ß-AR
subtype
|
G protein
Mediator
|
Second
Messenger
|
Subtype-selective Agonists
|
Subtypeselective Antagonists
|
b-AR protein
localization
|
|
ß1
|
Gs
|
cAMP
|
Ro 363
xameterol
denopamine
|
metoprolol
practolol
atenolol
betaxolol
CGP20712A
|
Cingulate cortex,
cerebral cortex,
hippocampus,
thalamus,
substantia nigra,
olfactory tubercle,
nuclei of medulla
|
|
ß2
|
Gs
|
cAMP
|
Terbutaline
salbutamol
salmeterol
zinterol
|
Butoxamine
ICI 118,551
oxprenolol
|
Cerebellum,
pia mater,
thalamic nuclei,
neostriatum,
cerebral cortex,
substantia nigra,
olfactory tubercle,
nuclei of medulla
|
|
ß3
|
Gs
Gi (?)
|
cAMP
|
CGP 12177
BRL 37344
pindolol
oxprenolol
|
None identified to date
|
hypothalamus
|