Figure 1
Sagittal section of the rat brain showing the origin and course of the dorsal and ventral noradrenergic bundles from the locus ceruleus (cell group A6)  (DNAB) and cell groups (A1-5,7) in the rostral medulla oblongata (VNAB). Also shown are the optimal parameters for making lesions of these projections using intracerebral administration of the catecholamine neurotoxin 6-hydroxydopamine. Terminal areas sustaining depletion are shaded. Typically greater than 90% depletion of neocortical and hippocampal NE is obtained following lesions of the DNAB (e.g. see ref. 14, 47) and about 70% of hypothalamic NE following depletion of the VNAB (see e.g. 14,78).  Abbreviations: ob=olfactory bulb; cc=cerebral cortex; hc=hippocampus.  Figure provided by B.J. Cole.

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published 2000