TABLE 1. Inhibitor Profiles for NET and SERT
 

Ki or Km (nM)a

Inhibitor

hNET

hSERT

Fluoxetine

—

3.1

Sertraline

—

0.8

Paroxetine

310

0.25

Citalopram

>1000

5.0

Imipramine

65

2.1

Desipramine

4.0

40

Clomipramine

—

0.3

Amitriptyline

100

15

Nortriptyline

16.5

130

D-Amphetamine

55

>10,000

Cocaine

140

4200

Nomifensine

8.0

840

Mazindol

1.4

100

5HT

>10,000

460

Norepinephrine

460

>10,000

Dopamine

140

>10,000

a The Ki or Km values were obtained from assays using cells transfected with cDNAs for indicated transporter as reported in refs. (50) and (52), and in unpublished results.

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published 2000