Figure 3.
Proposed transmembrane topology and structural features of SERT and NET subunits. Note the 12 proposed transmembrane domains (TMDs), the large extracellular loop between TMD3 and TMD4 bearing multiple N-linked glycosylation sites, cytoplasmic -NH2 and -COOH tails, and sites for potential intramolecular or intermolecular disulfide bridge formation and phosphorylation.
Back to Chapter

published 2000