Figure 2.
General model of ion-coupled NE and 5HT uptake. Left: Proposed mechanism for the 5HT transporter (SERT) whereby uptake of 5HT is dependent upon cotransport of Na+ and Cl- and countertransport of K+. Right: Norepinephrine transporter (NET) model showing Na+ and Cl--dependent NE uptake with intracellular K+ stimulation of NE uptake, but no associated K+ efflux. Both transporters are inhibited by antidepressants and cocaine. PM, plasma membrane.
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published 2000