|
D1-like group
|
D2-like group
|
|
|
|
|
|
D1
|
D5
|
D2
|
D3
|
D4
|
|
|
|
|
|
|
nM
|
nM
|
nM
|
nM
|
nM
|
|
|
|
|
|
|
Dopamine
|
8-10
|
2-10
|
2-10
|
3-10
|
2-10
|
|
|
|
|
|
Apomorphine
|
0.7
|
<1
|
0.7
|
0.4 f
|
|
|
|
|
|
|
Bromocriptine
|
550 b
|
450
|
5-10
|
5
|
290
|
|
|
|
|
|
(+)7-OH-DPAT (d)
|
|
|
|
3.6 e
|
0.5 e
|
|
|
|
|
|
Lisuride 6
|
|
0.6
|
|
|
|
|
|
|
|
|
Pergolide
|
0.8 b
|
~1?
|
~0.8
|
|
|
|
|
|
|
|
Naxagolide (a)
|
80
|
|
0.5
|
|
|
|
|
|
|
|
Quinpirole
|
1500
|
|
4.8
|
1.2 c
|
|
|
|
|
|
|
*: Data for receptors in either native tissues or
|
|
human cloned receptors (151)
|
|
Calf brain striatum or calf parathyroid used for native D1.
|
|
Pig anterior pituitary used for native D2.
|
|
a: Also known as (+)PHNO.
|
|
b: Acts as partial agonist or antagonist at D1.
|
|
"c: Ref, (96)"
|
|
d: (+)7-OH-dipropylaminotetralin
|
|
e: Ref. (54)
|
|
f: Ref. (27)
|
|
|