Figure 6.
The concentrations of various neuroleptics needed to occupy 75% of the D2 receptors, C75%, are essentially identical to the therapeutic concentrations of neuroleptics found in the spinal fluid or in the plasma water in patients. Because endogenous synaptic dopamine (153,164,166) competes with the neuroleptic, the C75% values were six times higher than the neuroleptic dissociation constants at the D2 receptor (Table 3).
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published 2000