Development of Mesencephalic Dopamine Neurons in the Nonhuman Primate

Relationship to Survival and Growth Following Neural Transplantation

J. R. Sladek, Jr. and B. Blanchard
Department of Neuroscience
The Chicago Medical School
North Chicago, Illinois 60064.

T. J. Collier
Department of Neurological Sciences
Rush Medical School
Chicago, Illinois 60612.

J. D. Elsworth, J. R. Taylor, R. H. Roth, and D. E. Redmond
Departments of Psychiatry and Pharmacology
Yale University School of Medicine
New Haven, Connecticut 06510.


REFERENCES

1. Bakay RAE, Fiandaca MS, Barrow DL, Schiff A, Collins DC. Preliminary report on the use of fetal tissue transplantation to correct MPTP-induced Parkinson-like syndrome in primates. Appl Neurophysiol 1985;48:358361.

2. Brundin P, Nilsson OG, Strecker RE, Lindvall O, Astedt B, Björklund A. Behavioral effects of human fetal dopamine neurons grafted in a rat model of Parkinson's disease. Exp Brain Res 1986;65:235240.

3. Brundin P, Strecker RE, Widner H, Clarke DJ, Nilsson OG, Astedt B, Lindvall O, Björklund A. Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behavior, and dopamine release. Exp Brain Res 1988;70:192208.

4. Coyle JT. The development of catecholaminergic neurons of the central nervous system. Neurosci Res 1973;5:3552.

5. Freeman TB, Spence MS, Boss BD, Spector DH, Strecker RE, Olanow CW, Kordower JH. Development of dopaminerig neurons in the human substantia nigra. Exp Neurol 1991;113:344353.

6. Freed CR, Breeze RE, Rosenberg NL, Schneck SA, Kriek E, Qi J-X, et al. Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for parkinson's disease. N Engl J Med 1992;327(2):1016.

7. Freed WJ. Substantia nigra grafts and Parkinson's disease: from animal experiments to human therapeutic trials. Res Neurol Neurosci 1991;3:109134.

8. Garver DL, Sladek JR Jr. Monoamine distribution in primate brain. I. Catecholamine-containing perikarya in the brain stem of Macaca speciosa. J Comp Neurol 1975;159:289304.

9. Golden GS. Prenatal development of the biogenic amine systems of the mouse brain. Dev Biol 1973;33:300311.

10. Hanaway J, McConnell JA, Netsky MG. Histogenesis of the substantia nigra, ventral tegmental area of Tsai and interpeduncular nucleus: an autoradiographic study of the mesencephalon in the rat. J Comp Neurol 1971;142:5973.

11. Lauder JM, Bloom FL. Ontogeny of monoamine neurons in the locus coeruleus, raphe nuclei and substantia nigra of the rat. J Comp Neurol 1974;155:469482.

12. Lauder JM, Krebs H. Effects of p-chlorophenylalanine on time of neuronal origin during embryogenesis in the rat. Brain Res 1976;107:638644.

13. Levitt P, Moore RY. Development of the noradrenergic innervation of neocortex. Brain Res 1979;162:243259.

14. Levitt P, Rakic P. The time of genesis, embryonic origin and differentiation of the brain stem monoamine neurons in the rhesus monkey. Dev Brain Res 1982;4:3557.

15. Lindvall O. Transplantation into the human brain: present status and future possibilities. J Neurol Neurosurg Psychiatry 1989:3954.

16. Lindvall O, Rehncrona S, Brundin P, et al. Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease. Arch Neurol 1989;46:615631.

17. Lindvall O, Brundin P, Widner H, et al. Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science 1990;247:574577.

18. Loizou LA. The postnatal ontogeny of monamine-containing neurones in the central nervous system of the albino rat. Brain Res 1972;40:395418.

19. Nobin A, Björklund. Topography of the monoamine neuron systems in the human brain as revealed in fetuses. Acta Physiol Scand Suppl 1973;388:140.

20. Olson L, Seiger Å. Early prenatal ontogeny of central monoamine neurons in the rat: fluorescence histochemical observations. Z Anat Entwicklungsgesch 1972;137:301316.

21. Olson L, Boreus LO, Seiger Å. Histochemical demonstration and mapping of 5-hydroxytryptamine- and catacholamine-containing neuron systems in the human fetal brain. Z Anat Entwicklungsgesch 1973;139:259282.

22. Olson L, Strömberg I, Bygdeman M, Granholm A-Ch, Hoffer B, Freedman R, Seiger Å. Human fetal tissues grafted to rodent hosts: structural and functional observations of brain, adrenal and heart tissues in oculo. Exp Brain Res 1987;67:163178.

23. Pearson J, Brandeis L, Goldstein M. Appearance of tyrosine hydroxylase immunoreactivity in the human embryo. Dev Neurosci 1980;3:140150.

24. Pickel VM, Spect LA, Krushdev KS, Joh TH, Reis DJ, Hervonen A. Immunocytochemical localization of tyrosine hydroxylase in the human fetal nervous system. J Comp Neurol 1980;194: 465474.

25. Redmond DE Jr, Roth RH, Elsworth JD, Sladek JR Jr, Collier TJ, Deutch AY, Haber SN. Fetal neuronal grafts in monkeys given methylphenyltetrahydropyridine. Lancet 1986;1125.

26. Schlumpf M, Shoemaker WJ, Bloom FE. Innervation of embryonic rat cerebral cortex by catecholamine-containing fibers. J Comp Neurol 1980;192:361376.

27. Seiger Å, Olson L. Late prenatal ontogeny of central monoamine neurons in the rat: fluorescence histochemical observations. Z Anat Entwicklungsgesch 1973;140:281318.

28. Silani V, Mariani D, Donato FM, Ghezzi C, Mazzucchelli F, Buscaglia M, et al. Development of dopaminergic neurons in the human mesencephalon and in vitro effects of basic fibroblast growth factor treatment. Exp Neurol 1994;[in press].

29. Sladek JR Jr, Collier TJ, Haber SN, Roth RH, Redmond DE Jr. Survival and growth of fetal cathecholamine neurons transplanted into primate brain. Brain Res Bull 1986;17:809818.

30. Sladek JR Jr, Elsworth JD, Roth RH, Evans LE, Collier TJ, Cooper SJ, Taylor JR, Redmond DE Jr. Fetal dopamine cell survival after transplantation is dramatically improved at a critical donor gestational age in nonhuman primates. Exp Neurol 1993;122:1627.

31. Sladek JR Jr, Gash DM. Nerve-cell grafting in Parkinson's disease. J Neurosurg 1988;68:337351.

32. Sladek JR Jr, Redmond DE Jr, Collier TJ, Haber SN, Elsworth JD, Duetch AY, Roth RH. Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism. Prog Brain Res 1987;71:309323.

33. Specht LA, Pickel VM, Joh TH, Reis DJ. Light-microscopic immunocytochemical localization of tyrosine hydroxylase in prenatal rat brain. I. Early ontogeny. J Comp Neurol 1981;199:233253.

34. Specht LA, Pickel VM, Joh TH, Reis DJ. Light-microscopic immunocytochemical localization of tyrosine hydroxylase in prenatal rat brain. II. Late ontogeny. J Comp Neurol 1981;199:255276.

35. Spencer DD, Robbins RJ, Naftolin F, Phil D, Marek KL, Vollmer T, Leranth C, Roth RH, Price LH, Gjedde A, Bunney BS, Sass KJ, Elsworth JD, Kier EL, Makuch R, Hoffer PB, Redmond DE Jr. Unilateral transplantation of human fetal mesencephalic tissue into the caudate nucleus of patients with Parkinson's disease. N Eng J Med 1992;327(22):15411548.

36. Strömberg I, Bygdeman M, Goldstein M, Seiger Å, Olson L. Human fetal substantia nigra grafted to the dopamine-denervated striatum if immunosuppressed rats: evidence for functional reinnervation. Neurosci Lett 1986;71:271276.

37. Tennyson VM, Barrett RE, Cohen G, Cote L, Heikkila R, Mytilineou C. The developing neostriatum of the rabbit: correlation of [fcfluorescence histochemistry, electron microscopy, endogenous dopamine levels and H3-dopamine uptake. Brain Res 1972;46:251255.

38. Tennyson VM, Mytilineou C, Barrett RE. Fluorescence and electron microscopic studies of the early development of the substantia nigra and area ventralis tegmenti in the fetal rabbit. J Comp Neurol 1973;149:233258.

39. Thompson WG. Successful brain grafting. NY Med J 1890;51:701.

40. Voorn P, Kalsbeek A, Jorritsma-Byham, Groenewegen HJ. The pre-and postnatal development of the dopaminergic cell groups in the ventral mesencephalon and the dopaminergic innervation of the striatum of the rat. Neuroscience 1988;25:857887.

41. Widner H, Tetrud J, Rehngrona S, Snow B, Brundin P, Gustavii B, et al. Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). N Eng J Med 1992;327(22):15561563.

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published 2000