TABLE 4. Autoradiographic analysis of the distribution of M1, M2, and non-M1, non-M2 subtypes of the muscarinic receptor in various regions of the rat braina

Regional binding

(fmol/mg tissue wet wt)

Brain region

M1

M2

Non-M1,

non-M2

Cerebral cortex

Frontoparietal cortex,

somatosensory area

Layers I-II

244

24

292

Layers III-IV

162

9

219

Layer V

132

15

238

Layer VI

166

9

179

Primary olfactory cotex

252

9

239

Subcortical telencephalon

Olfactory bulb, external

plexiform layer

149

57

340

Anterior olfactory nucleus

254

12

270

Olfactory tubercle

193

18

413

Lateral septum

52

25

191

Medial septum

26

22

76

Vertical limb, diagonal band

41

9

86

Islands of Calleja

243

24

417

Caudate putamen

263

27

389

Nucleus accumbens

228

15

371

Basolateral amygdala

204

16

156

Lateral amygdala

181

21

177

Hippocampal subfields

     

CA1, oriens

CA1, pyramidale

CA1, radiatum

CA3

Dentate gyrus

259

259

259

143

270

9

9

9

6

6

254

232

279

154

195

Diencephalon

Ventrolateral thalamic

nucleus

30

6

58

Anteroventral thalamic

nucleus

39

34

166

Medial geniculate nucleus

50

6

95

Anterior hypothalamic

nucleus

25

13

60

Ventromedial hypothalamic

nucleus

27

12

58

Mesencephalon

Superior colliculus

Inferior colliculus

Central gray

29

22

20

54

18

15

147

61

84

Rhombencephalon

Motor trigeminal nucleus

Cerebellum lobules

36

21

57

a Data are from Smith et al. (66). The binding values do not represent absolute receptor densities, but rather the magnitude of radioligand binding measured under the conditions of the experiment.

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published 2000