TABLE 3. Dissociation constants of subtype selective antagonists for native muscarinic receptorsa

-Log (KD)

 
M1
M2
M3

Antagonists

Binding

Function

Binding

Function

Binding

Function

Atropine

9.4

9.3

9.1

9.0

9.5

9.1

Pirenzepine

8.0

8.0

6.1

6.5

6.6

6.9

AF-DX 116

6.5

6.9

7.3

7.2

6.0

6.2

HHSiD

7.8

7.7

6.7

6.4

8.1

7.9

4-DAMP

9.1

9.1

8.2

7.8

8.9

8.8

a The binding data were taken from Pedder et al. (59), except for the values for 4-DAMP which were taken from Delmendo et al. (14). The functional estimates are the means of values taken from Barlow et al. (2), Eltze 22, Giachetti et al. 30, and Lambrecht et al. 47. Other details are given in the text.

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published 2000