TABLE 1. Glutamate receptor pharmacologya

NMDA

AMPA

Competitive

Modulatory

Competitive

Modulatoryb

Kainate

Metabotropic

Agonists

NMDA

l-CCG-IV

ACBD

Glycine

AMPA

ATPA

5-Fluorowillardiine

Br-HIBO

Aniracetam

1-BCP

Cyclothiazide

Kainate

Domoate

trans-ACPD

l-CCG-I

l-AP4

3,5-Dihydroxy-

phenylglycine

trans-2,4-ADA

Antagonists

d-AP5

CGS19755

CGP37849

d-CPP

d-CPPene

7-Chloro-

kynurenate

5,7-Dichloro-

kynurenate

MNQX

L689,560

HA966

NBQX

GYKI 52466

l-AP3

(+)-MCPG

(S)-4CPG

Channel blockers

MK801

PCP

a This table provides a partial list of agonists and antagonists of each receptor type with emphasis on the more selective agents. Abbreviations: l-CCG-IV, (2S,3R,4S)-a(carboxycyclopropyl)glycine; d-AP5, d-2-amino-5-phosphonopentanoic acid; ACBD, 1-amincyclobutane-1,3-dicarboxylate; CGS19755, cis-4-(phosphonomethyl)piperidine-2-carboxylic acid; CGP37849, d,l-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid; CPP, 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid; CPPene, (E)-4-(3-phosphono-2-propenyl)piperaziiine-2-carboxylic acid; MK801, dizocilpine; PCP, phencyclidine; MNQX, 5,7-dinitroquinoxaline-2,3-dione; L689,560, ()-4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4,-tetrahydroquinoline; ATPA, a-amino-3-hydroxy-5-tertbutyl-4-isoxazole-propionate; HA966, 3-amino-1-hydroxypyrrolidin-2-one; Br-HIBO, (S)-4-bromohomoibotenate; NBQX, 2,3-dihydro-6-nitro-7-sulfamoyl-benzo(F)-quinoxaline; aniracetam,1-(4-methoxybenzoyl)-2-pyrrolidinone; 1-BCP, 1-(1,3-benzodioxol-5-ylcarbonyl)-piperidine; GYKI 52466, 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine; trans-ACPD, 1-aminocyclopentane-trans-1,3-dicarboxylic acid; L-CCG-I, (2S,3S,4S)-a-(carboxycyclopropyl)glycine; L-AP-4, L-2-amino-4-phosphonobutyric acid; trans-2,4-ADA, trans-azetidine-2,4-dicarboxylic acid; L-AP-3, L-2-amino-3-phosphonopropionic acid; (+)-MCPG, (+)-a-methyl-4-carboxyphenylglycine; (S)-4CPG, (S)-4-carboxyphenylglycine.

b The sites of action of the non-competitive modulators of AMPA receptors have not been well-characterized.

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published 2000