Figure 4.

Following at least 5 weeks of successful treatment with serotonin reuptake inhibitors (SRI), 15 patients diagnosed with obsessive-compulsive disorder received 2 tests 7-10 days apart, a tryptophan-containing amino acid drink (control nondepletion) and an amino acid drink without tryptophan (active depletion).  Ratings before the drink were subtracted from ratings 7 hrs. after the drink to obtain the drink effect for each of the control and active drinks.  The change plotted above is the active drink effect minus the control drink effect (adapted from Barr et al. - 4).

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published 2000