PART I. PRECLINICAL SECTION
Introduction
Introduction to Preclinical Neuropsychopharmacology: Floyd E. Bloom
Critical Analysis of Methods
Basic Concepts and Techniques of Molecular Genetics: Samuel H. Barondes
Cytology and Circuitry: Stanley J. Watson, Jr. and William E. Cullinan
A Critical Analysis of Neurochemical Methods for Monitoring Transmitter Dynamics in the Brain: Janet M. Finlay and Gwenn S. Smith
Electrophysiology: Gary S. Aston-Jones and George R. Siggins
Behavioral Techniques in Preclinical Neuropsychopharmacology Research: James E. Barrett and Klaus A. Miczek
Transmitter Systems
Amino Acids
Excitatory Amino Acid Neurotransmission: Carl W. Cotman, Jennifer S. Kahle, Stephan E. Miller, Jolanta Ulas, and Richard J. Bridges
GABA and Glycine: Steven M. Paul
Acetylcholine
Neuronal Nicotinic Acetylcholine Receptors: Novel Targets for CNS Therapeutics: Michael W. Decker, James P. Sullivan, Stephen P. Arneric, and Michael Williams
Molecular Biology, Pharmacology, and Brain Distribution of Subtypes of the Muscarinic Receptor: Frederick J. Ehlert, William R. Roeske, and Henry I. Yamamura
Cholinergic Transduction: Elliott Richelson
Structure and Function of Cholinergic Pathways in the Cerebral Cortex, Limbic System, Basal Ganglia, and Thalamus of the Human Brain: Marek-Marsel Mesulam
Functional Heterogeneity of Central Cholinergic Systems: Peter B. Reiner and H. Christian Fibiger
Amines
Molecular Biology of the Dopamine Receptor Subtypes: Olivier Civelli
Electrophysiological Properties of Midbrain Dopamine Neurons: Anthony A. Grace and Benjamin S. Bunney
The Dopamine Transporter: Potential Involvement in Neuropsychiatric Disorders: Michael J. Bannon, Paola Sacchetti and James G. Granneman
Long-and Short- Term Regulation of Tyrosine Hydroxylase: Menek Goldstein
Colocalization in Dopamine Neurons: Ariel Y. Deutch and Andrew J. Bean
Dopamine Receptor Expression in the Central Nervous System: Alfred Mansour and Stanley J. Watson, Jr.
Dopamine Autoreceptor Signal Transduction and Regulation: Louis A. Chiodo, Arthur S. Freeman, and Benjamin S. Bunney
Biochemical Pharmacology of Midbrain Dopamine Neurons: Robert H. Roth and John D. Elsworth
Dopaminergic Neuronal Systems in the Hypothalamus: Kenneth E. Moore and Keith J. Lookingland
Electron Microscopy of Central Dopamine Systems: Virginia M. Pickel and Susan R. Sesack
Development of Mesencephalic Dopamine Neurons in the Nonhuman Primate: Relationship to Survival and Growth Following Neural Transplantation: John R Sladek, Jr., Barbara Blanchard, T. J. Collier, John D Elsworth, Jane R. Taylor, Robert H. Roth, and D. Eugene Redmond, Jr.
Mesocorticolimbic Dopaminergic Neurons: Functional and Regulatory Roles: Michel Le Moal
Dopamine Receptor Transcript Localization in Human Brain: James H. Meador-Woodruff
Dopamine Receptors: Clinical Correlates: Philip Seeman
Signal Transduction Pathways for Catecholamine Receptors: Ronald S. Duman and Eric J. Nestler
Norepinephrine and Serotonin Transporters: Molecular Targets of Antidepressant Drugs: Eric L. Barker and Randy D. Blakely
Pharmacology and Physiology of Central Noradrenergic Systems: Stephen L. Foote and Gary S. Aston-Jones
Coexisting Neurotransmitters in Central Noradrenergic Neurons: Philip V. Holmes and Jacqueline N. Crawley
Modification of Central Catecholaminergic Systems by Stress and Injury: Functional Significance and Clinical Implications: Elizabeth D. Abercrombie and Michael J. Zigmond
Central Norepinephrine Neurons and Behavior: Trevor W. Robbins and Barry J. Everitt
The Noradrenergic Receptor Subtypes: Magdalena Wozniak, Nicole L. Schramm and Lee E. Limbird
Physiological and Anatomical Determinants of Locus Coeruleus Discharge: Behavior and Clinical Implications: Rita J. Valentino and Gary S. Aston-Jones
Noradrenergic Neural Substrates for Anxiety and Fear: Clinical Associations Based on Preclinical Research: Dennis S. Charney, J. Douglas Bremner, and D. Eugene Redmond, Jr.
Histamine: Jean-Charles Schwartz, Jean-Michel Arrang, and Monique Garbarg
Molecular Biology of Serotonin Receptors: A Basis for Understanding and Addressing Brain Function: Jean Chen Shih, Kevin J.-S. Chen, and Timothy K. Gallaher
Serotonin Receptor Subtypes and Ligands: Richard A. Glennon, Malgorzata Dukat, and Richard B. Westkaemper
Gene Targeting Approaches to Serotonin Receptors: Laurence Tecott, M.D., Ph. D.
Serotonin Receptors: Signal Transduction Pathways: Elaine Sanders-Bush and Herv Canton
Anatomy, Cell Biology, and Maturation of the Serotonergic System: Neurotrophic Implications for the Actions of Psychotropic Drugs: Efrain C. Azmitia
Electrophysiology of Serotonin Receptor Subtypes and Signal Transduction Pathways: George K. Aghajanian
Serotonin and Behavior: A General Hypothesis: Barry L. Jacobs and Casimir A. Fornal
Indoleamines: The Role of Serotonin in Clinical Disorders: George R. Heninger
Monoamine Oxidase: Basic and Clinical Perspectives:D.P. Holschneider, M.D., J.C. Shih, Ph.D.
Peptides
General Overview of Neuropeptides: Tomas Hakfelt, Zhi-Qing David Xu, Christian Broberger, Tiejun Sten Shi, and Xu Zhang
Thyrotropin-Releasing Hormone: Focus on Basic Neurobiology: George A. Mason, James C. Garbutt, and Arthur J. Prange, Jr.
Corticotropin-Releasing Factor: Physiology, Pharmacology, and Role in Central Nervous System and Immune Disorders: Errol B. De Souza and Dimitri Goriadis
Neuropharmacology of Endogenous Opioid Peptides: John J. Wagner and Charles I. Chavkin
Vasopressin and Oxytocin in the Central Nervous System: Linda Rinaman, Thomas G. Sherman, and Edward M. Stricker
Neuropeptide Y and Related Peptides: Claes Wahlestedt and Markus Heilig
Somatostatin in the Central Nervous System: David R. Rubinow, Candace L. Davis, and Robert M. Post
Galanin: A Neuropeptide with Important Central Nervous System Actions: Tamas Bartfai
The Neurobiology of Neurotensin: Garth Bissette and Charles B. Nemeroff
Cholecystokinin: Margery C. Beinfeld
Vasoactive Intestinal Peptide in Central Nervous:Douglas E. Brenneman, Joanna M. Hill, and Illana Gozes
Luteinzing Hormone-Releasing Hormone Neuronal: Serge Rivest and Leonello Cusan
New Transmitters
Arachidonic Acid: Daniele Piomelli
Nitric Oxide and Related Substance as Neural Messengers: Solomon H. Snyder and Ted M. Dawson
Neuronal Growth and Differentiation Factors and Synaptic Placticity: Paul H. Patterson
Proto-Oncogenes: Beyond Second Messengers: James I. Morgan and Thomas E. Curran
Purinergic Mechanisms in Nervous System Function and Disease States: Michael F. Jarvis and Michael Williams
Integrative Concepts
Brain Energy Metabolism: An Integrated Cellular Perspective: Pierre J. Magistretti, Luc Pellerin, and Jean-Luc Martin
Molecular and Cellular Mechanisms of Brain Development: David A. Morilak, Matthew H. Porteus, and Roland D. Ciaranello
The Development of Brain and Behavior: Thomas R. Insel
Intracellular Messenger Pathways as Mediators of Neural Plasticity: Eric J. Nestler and Ronald S. Duman
Neuroendocrine ions: Bruce S. McEwen
Interactions Between the Nervous System and the Immune System: Implications for Psychopharmacology: Adrian J. Dunn
Adaptive Processes Regulating Tolerance to Behavioral Effects of Drugs:Alice M. Young and Andrew J. Goudie
The Psychopharmacology of Sexual Behavior: James G. Pfaus and Barry J. Everitt
Animal Models of Drug Addiction: George F. Koob
Stress: Huda A. Akil and M. Inés Morano
Circadian Rhythms: C.S. Colwell
Processes Underlying Sleep Regulation: Alexander A. Borbely, Peter Achermann, Beat Geering, and Irene Tobler
Animal Models of Psychiatric Disorders: Mark A. Geyer and Athina Markou
Genetic Stategies in Preclinical Subtsance Abuse Research: Kaitlin E. Browman, John Crabbe, and Ting-Kai Li
Molecular Analysis of the Single Cell: Importance: James Eberwine, Peter Crino, Steve Arnold, John Trojanowski, and Scott Hemby
Astroglial Pharmacology: Elisabeth Hansson, Thorleif Thorlin, Mattias Linde, Fredrik Blomstrand, Peter S. Eriksson, Ulrika Johansson, Siamak Khatibi, Michael Nilsson, Torsten Olsson, David Auberg and Lars Ronnback
Molecular Neurobiology of Development: Flora M. Vaccarino and James F. Leckman
PART II. CLINICAL SECTION
Introduction
Introduction to Clinical Neuropsychopharmacology: David J. Kupfer
Critical Analysis of Methods
The DSM-IV Classification and Psychopharmacology:Allen Frances, Avram H. Mack, Ruth Ross, and Michael B. First
Clinical Study Designâ€"Critical Issues: Donald S. Robinson, M.D. and Nina R. Schooler, Ph.D.
Short-and Long-Term Psychopharmacological Treatment Strategies: Ira D. Glick, David L. Braff, and David S. Janowsky
Pharmacokinetics and Pharmacodynamics: David J. Greenblatt, Jerold S. Harmatz, Lisa L. von Moltke, and Richard I. Shader
Cytochrome Enzymes and Psychopharmacology: Sheldon H. Preskorn, M.D. and Anne T. Harvey, Ph.D.
Methodological Issues in the Neuropathology of Mental Illness: Joel E. Kleinman, Thomas M. Hyde, and Mary M. Herman
Positron and Single Photon Emission Tomography: Principles and Applications in Psychopharmacology: Robert T. Malison, Marc Laruelle, and Robert B. Innis
In Vivo Structural Brain Assessment: Kelvin O. Lim, Margaret Rosenbloom, and Adolf Pfefferbaum
Methodological Issues in Event-Related Brain Potential and Magnetic Field Studies: Walton T. Roth, Judith M. Ford, Adolf Pfefferbaum, and Thomas R. Elbert
Psychiatric Genetics: Joel Gelernter and David Goldman
Psychiatric Disorders
Mood Disorders
Recent Studies on Norepinephrine Systems in Mood Disorders: Alan F. Schatzberg and Joseph J. Schildkraut
Dopaminergic Mechanisms in Depression and Mania: Paul Willner
The Serotonin Hypothesis of Major Depression: Michael Maes and Herbert Y. Meltzer
The Role of Acetylcholine Mechanisms in Affective Disorders: David S. Janowsky and David H. Overstreet
Neuroendocrinology of Mood Disorders: Florian Holsboer
Neuropeptide Alterations in Mood Disorders: Paul M. Plotsky, Michael J. Owens, and Charles B. Nemeroff
Psychoneuroimmunology of Depression: Michael Irwin
Biological Rhythms in Mood Disorders: Anna Wirz-Justice
Brain Imaging in Mood Disorders: Godfrey D. Pearlson, MD and Thomas E. Schlaepfer, MD
Mood Disorders Linked to the Reproductive Cycle in Women: Barbara L. Parry and Patricia Haynes
Selective Serotonin Reuptake Inhibitors in the Acute Treatment of Depression: Stuart A. Montgomery
Standard Antidepressant Pharmacotherapy for the Acute Treatment of Mood Disorders: Michael J. Burke, M.D., Ph.D. and Sheldon H. Preskorn, M.D.
Long-Term Treatment of Mood Disorders: Robert F. Prien and James H. Kocsis
Treatment-Resistant Depression: Michael E. Thase and A. John Rush
Lithium and the Anticonvulsants in Bipolar Disorder: Joseph R. Calabrese and Charles Bowden
Psychosocial Predictors of Outcome in Depression: Robert M. A. Hirschfeld
Electroconvulsive Therapy: Harold A. Sackeim, D. P. Devanand, and Mitchell S. Nobler
Novel Pharmacological Approaches to the Treatment of Depression: Denis L. Murphy, Philip B. Mitchell, and William Z. Potter
The Neurobiology of Treatment-Resistant Mood Disorders: Robert M. Post and Susan R. B. Weiss
Schizophrenia
Neurodevelopmental Perspectives on Schizophrenia: Daniel R. Weinberger
Physiological Indicators of the Schizophrenia Phenotype: Robert Freedman, Randal G. Ross, and Lawrence E. Adler
Functional Brain-Imaging Studies in Schizophrenia: Raquel E. Gur
New Developments in Dopamine and Schizophrenia: René S. Kahn and Kenneth L. Davis
Schizophrenia and Glutamate: An Update: Blynn Garland Bunney, Ph.D. William E. Bunney, Jr., M.D. and Arvid Carlsson
The Role of Serotonin in Schizophrenia: Herbert Y. Meltzer, M.D., Ph.D. and Bryan Roth, M.D.
The Effects of Neuroleptics on Plasma Homovanillic Acid: Arnold J. Friedhoff and Raul R. Silva
Neurophysiological and Psychophysiological Approaches to Schizophrenia: Keith H. Nuechterlein, Ph.D.
Neurocognitive Functioning in Patients with Schizophrenia: An Overview: Terry E. Goldberg and James M. Gold
Acute Treatment of Schizophrenia: William C. Wirshing, M.D., Donna Ames-Wirshing, M.D., Stephen R. Marder, M.D., and Theodore Van Putten, M.D.
Maintenance Drug Treatment for Schizophrenia: John G. Csernansky
Atypical Antipsychotic Drugs: Herbert Y. Meltzer
Anxiety Disorders
Neuroimaging Studies of Human Anxiety Disorders: Cutting Paths of Knowledge through the Field of Neurotic Phenomena: Lewis R. Baxter, Jr.
Anxiety and Serotonin1A Receptor: Jeremy D. Coplan, Susan I. Wolk, and Donald F. Klein
Pharmacological Challenges in Anxiety Disorders: Lawrence H. Price, Andrew W. Goddard, Linda C. Barr, and Wayne K. Goodman
Environmental Factors in the Etiology of Anxiety: Karrie J. Craig, Kelly J. Brown, and Andrew Baum
The Pharmacotherapy of Acute Anxiety: A Mini-Update: Richard I. Shader and David J. Greenblatt
Issues Long-Term Treatment of Anxiety Disorders: Edward Schweizer, Karl Rickels, and Eberhard H. Uhlenhuth
Post-Traumatic Stress Disorder : Matthew A. Friedman
Pharmacotherapy of Panic Disorder: Smit S. Sinha, Justine Kent, and Jack M. Gorman
Geriatric Disorders
Towards an Understanding of the Genetics of Alzheimer's Disease: Corrine L. Lendon and Alison M. Goate
Amyloidogenesis in Alzheimer's Disease and Animal Models: Sangram S. Sisodia, and Donald L. Price
Neuropsychological Assessment of Patients with Alzheimer's Disease: Richard C. Mohs
Biological Markers in Alzheimer's Disease: Trey Sunderland, Susan E. Molchan, and George S. Zubenko
Anatomic and Functional Brain Imaging in Alzheimer's Disease: Stanley I. Rapoport
Experimental Therapeutics: Deborah B. Marin and Kenneth L. Davis
Alzheimer's Disease: Treatment of Noncognitive Behavioral Abnormalities: Murray A. Raskind
Late-Onset Schizophrenia and Other Related Psychoses: Dilip V. Jeste, Jane S. Paulsen, and M. Jackuelyn Harris
Cognitive Impairment in Geriatric Schizophrenic Patients: Clinical and Postmortem Characterization: Michael Davidson and Vahram Haroutunian
Psychotropic Drug Metabolism in Old Age: Principles and Problems of Assessment: Lisa L. von Moltke, David J. Greenblatt, Jerold S. Harmatz and Richard I. Shader
Pharmacological Treatment of Depression in Late Life: Carl Salzman, Lon S. Schneider, and George S. Alexopoulos
Neurologic Disorders
Parkinson's Disease: Amos D. Korczyn
Tardive Dyskinesia: Epidemiological and Clinical Presentation: John M. Kane. M.D.
Tardive Dyskinesia: Pathophysiology: Daniel E. Casey
The Treatment of Tardive Dyskinesias: George Gardos and Jonathan O. Cole
Multi-Infarct Dementia: David S. Geldmacher and Peter J. Whitehouse
Prion Diseases: Stephen J. DeArmond and Stanley B. Prusiner
Amyotrophic Lateral Sclerosis, Glutamate, and Oxidative Stress: Andreas Plaitakis and P. Shashidharan
Neuropsychiatric Manifestations of HIV-1 Infection and AIDS: Robert A. Stern, Diana O. Perkins, and Dwight L. Evans
Potential Mechanisms of Neurologic Disease in HIV Infection: Melvyn P. Heyes
Huntington's Disease: Jang-Ho J. Cha and Anne B. Young
Personality Disorders
The Neuropsychopharmacology of Personality Disorders: Emil F. Coccaro and Larry J. Siever
Eating Disorders
Psychopharmacology of Anorexia Nervosa, Bulimia Nervosa, and Binge Eating : B. Timothy Walsh and Michael J. Devli
Obesity, Fat Intake and Chronic Disease: George A. Bray
Basic Biological Overview of Eating Disorders: Katherine A. Halmi
Pharmacological Treatment of Obesity: Gerald Curzonand E. Leigh Gibson
Sleep Disorders
Disordered Sleep: Developmental and Biopsychosocial Perspectives on the Diagnosis and Treatment of Persistent Insomnia: Charles F. Reynolds III, Daniel J. Buysse, and David J. Kupfer
Childhood Disorders
Early-Onset Mood Disorder: David A. Brent, M.D., Neal Ryan,M.D., Ronald Dahl, M.D., and Boris Birmaher, M.D.
The Interface of Genetics, Neuroimaging and Neurochemistry in Attention-Deficit Hyperactivity Disorder: Monique Ernst and Alan Zametkin
Autism and Pervasive Developmental Disorders: Linda J. Lotspeich
Tic Disorders: James F. Leckman, Bradley S. Peterson, and David L. Pauls
Eating Disturbances and Eating Disorders in Childhood: Regina C. Casper
Childhood Anxiety Disorders: Susan Jo Perlmutter, M.D.
Substance Abuse
Cocaine: Chris-Ellyn Johanson and Charles R. Schuster
Caffeine A Drug of Abuse?: Roland R. Griffiths and Geoffrey K. Mumford
Chronic Amphetamine Use and Abuse: Everett H. Ellinwood, M.D., George. King, Ph.D., Tong H. Lee, M.D., Ph.D.
Pathophysiology of Tobacco Dependence: Jack E. Henningfield, Leslie M. Schuh, and Murray E. Jarvik
Opioids: George E. Bigelow and Kenzie L. Preston
Pharmacotherapy of Alcoholism: Charles P. O'Brien, Margaret R. Rukstalis, and Michael F. Stromberg
Marijuana: Billy R. Martin
Phencyclidine: David A. Gorelick and Robert L. Balster
Abuse and Therapeutic Use of Benzodiazepines and Benzodiazepine-Like Drugs: James H. Woods, Jonathan L. Katz, Gail Winger
Barbiturates: Neil Harrison, Wallace Mendelson and Harriet de Wit
Genetic Influences in Drug Abuse: George R. Uhl, Gregory I. Elmer, Michele C. LaBuda, and Roy W. Pickens
Behavioral Treatment of Drug and Alcohol Abuse: Maxine L. Stitzer and Stephen T. Higgins
Integrative Concepts
Genetics: Raymond R. Crowe, MD
Strategies for Multimodality Research: Ellen Frank, David J. Kupfer, and Jordan Karp
Methodological and Statistical Progress in Psychiatric Clinical Research: A Statisticianâ€TMs Perspective: Helena Chmura Kraemer, Ph.D.
PART III. SPECIAL TOPICS
New Drug Design in Psychopharmacology: The Impact of Molecular Biology: John F. Tallman and Svein G. Dahl
Ethical Issues in Genetic Screening and Testing, Gene Therapy, and Scientific Conduct: Lisa S. Parker and Elizabeth Gettig
Psychiatric Genetic Counseling: Debby Tsuang, M.D., M.Sc., Stephen V. Faraone, Ph.D., and Ming T. Tsuang, MD, Ph.D. D.Sc., FRCPsych.
The Economics of Psychotropic Drug Development: Joseph A. DiMasi and Louis Lasagna
Economic Evaluation of Drug Treatment for Psychiatric Disorders: The New Clinical Trial Protocol: Gary A. Zarkin, Ph.D.
Ethnicity, Culture, and Psychopharmacology: Keh-Ming Lin and Russell E. Poland
Neurobiology of Suicide & Aggression: J. John Mann, M.D.